肺癌术中胸腔喷洒甘露聚糖肽和5-氟尿嘧啶的临床观察

Clinical Observation of Spraying Mannatide and 5-fluorouracil in Anocelia during Surgery of Lung Cancer

目的：观察在辅助化疗基础上于肺癌术中胸腔喷洒甘露聚糖肽和5-氟尿嘧啶的疗效及安全性。方法：将行肺癌根治术的114例患者随机分为观察组（59例）和对照组（55例）,观察组患者术中喷洒甘露聚糖肽（40~80 mg）和5-氟尿嘧啶（500 mg）;对照组患者未喷洒任何药物。两组Ⅱ期以上患者术后均常规行辅助化疗,21 d为1个周期,连续化疗2个周期。比较两组患者术后出血量、引流量、住院天数及并发症情况,毒副反应,KPS评分及体质量变化,免疫功能指标,生存率及复发率。结果：两组患者术后出血量、引流量、住院天数及并发症情况比较差异均无统计学意义（P〉0.05）。观察组患者恶心呕吐、白细胞减少发生情况显著优于对照组,KPS评分改善总有效率、体质量好转率均显著优于对照组,免疫功能指标显著优于对照组,1年和2年生存率显著优于对照组,2年内复发率、复发时间显著优于对照组,差异均有统计学意义（P〈0.01或P〈0.05）。结论：在辅助化疗基础上于肺癌术中胸腔喷洒甘露聚糖肽和5-氟尿嘧啶能降低患者毒副反应,改善免疫功能,提高生存率,降低复发率和推迟复发。

OBJECTIVE：To observe the efficacy and safety of spraying mannatide and 5-fluorouracil in anocelia during surgery of lung cancer based on the adjuvant chemotherapy. METHODS：Totally 114 patients with lung cancer radical surgery were randomly divided into observation group（59 cases）and control group（55 cases）. There were spraying mannatide（40-80 mg）and5-fluorouracil（500 mg）in the observation group;and nothing drugs were sprayed in control group. The patients higher than phaseⅡ were treated by adjuvant chemotherapy after surgery for continuous 2 cycles,21 d as a cycle. The clinical data was compared,including amount of bleeding and drainage,hospital stay,complications,toxicity,KPS score,body weight changes,immune function,survival rate and recurrence rates between 2 groups. RESULTS：There were no significant differences among the amount of bleeding and drainage,hospital stay and complications in the 2 groups（P〉0.05）. The nausea,vomiting,leucopenia,the KPS score,improvement of total effective rate,and improvement rate of body mass,immune function,survival rate in 1 and 2 year（s）,recurrence rate and time within 2 years in observation group were significantly better than control group,with significant differences（P〈0.01 or P〈0.05）. CONCLUSIONS：Spraying mannatide and 5-fluorouracil can reduce the toxicity in anocelia during surgery of lung cancer based on the adjuvant chemotherapy,improve the immune function and survival rate,reduce recurrence rate and prolong the recurrence time.