脉络宁注射液治疗支气管哮喘急性发作期的临床观察

Clinical Observation of Mailuoning Injection in the Treatment of Acute Bronchial Asthma

目的:观察脉络宁注射液治疗支气管哮喘急性发作期的临床疗效及安全性。方法:将92例支气管哮喘急性发作期患者随机均分为对照组和观察组。对照组患者给予吸氧、糖皮质激素、β2受体激动药、氨茶碱、抗感染等常规治疗。观察组患者在对照组治疗基础上加用脉络宁注射液20 ml加入5%葡萄糖注射液或0.9%氯化钠注射液500 ml中静脉滴注,每日1次。两组患者疗程均为14 d。观察两组患者的临床疗效,治疗前后血液流变学指标、肺功能指标、血浆6-酮-前列腺素1α(6-keto-PGF1α)水平及不良反应发生情况。结果:观察组患者总有效率显著高于对照组,差异有统计学意义(P<0.05)。治疗后,两组患者血液流变学指标、肺功能指标、血浆6-keto-PGF1α水平均显著优于同组治疗前,且观察组优于对照组,差异均有统计学意义(P<0.05)。两组患者均未见明显不良反应发生。结论:在常规治疗基础上加用脉络宁注射液可提高支气管哮喘急性发作期患者的疗效,且安全性较好。

OBJECTIVE：To observe the clinical efficacy and safety of Mailuoning injection in the treatment of acute bronchial asthma. METHODS：92 patients with acute bronchial asthma were randomly divided into control group and observation group. Patients in control groups were received routine treatment,including oxygen inhalation,glucocorticoid,β2agonists,aminophylline and anti-infection,etc. Patients in observation group were added Mailuoning injection 20 ml adding into 5% glucose injection or0.9% sodium chloride injection 500 ml by intravenous infusion,once a day,based on the treatment of control group. The course was 14 d. The clinical data was observed,including clinical efficacy,hemorheology indicators,pulmonary function,6-keto-PGF1αlevel and incidence of adverse reactions before and after treatment. RESULTS：The total effective rate in observation group was significantly higher than control group,with significant difference（P〈0.05）. After treatment,the hemorheology indicators,lung function indicators and 6-keto-PGF1α level in 2 groups were significantly better than before,and observation group was better than control group,with significant difference（P〈0.05）. There were no obvious adverse reactions. CONCLUSIONS：Routine treatment combined with Mailuoning injection can effectively improve the efficacy of acute bronchial asthma with good safety.