基于马尔可夫模型比较丙戊酸钠、托吡酯和苯妥英钠治疗癫痫的经济性

Comparison of Economy among Antiepileptic Agents Sodium Valproate,Topiramate and Dipheninum Based on Markov Model

目的:比较丙戊酸钠、托吡酯和苯妥英钠治疗癫痫的经济性。方法:计算机检索Pro Quest、Pub Med、Springer、中国期刊全文数据库、中文科技期刊全文数据库、万方数字化期刊全文数据库,收集关于丙戊酸钠、托吡酯和苯妥英钠治疗癫痫的经济性研究,运用Tree Age Pro 2011.1.0.12.1软件构建马尔可夫(Markov)模型,通过计算成本-效果比(CER)对3种药物的经济性作出评价。结果:共纳入6项研究。苯妥英钠的CER值为29.99,丙戊酸钠的CER值为2 664.52,托吡酯的CER值为6 657.25,即苯妥英钠<丙戊酸钠<托吡酯。结论:单从经济学方面考虑,苯妥英钠是治疗癫痫最经济、有效的药物。由于纳入研究数量偏少,该结论有待大样本、高质量的研究进一步验证。

OBJECTIVE：To compare economy among sodium valproate（VPA）,topiramate（TPM） and dipheninum（DPH）in the treatment of epilepsy（EP）. METHODS：Retrieved from Pro Quest,Pub Med,Springer,CJFD,VIP,Wanfang database,researches about economy among VPA,TPM and DPH in the treatment of EP were collected. Tree Age Pro 2011.1.0.12.1 software was used to establish Markov model,and cost-effectiveness ratios（CER）of them were calculated to evaluate their economy. RESULTS：CER of DPH,VPA,TPM were 29.99,2 664.52 and 6 657.25,in ascending order of DPHVPATPM. CONCLUSIONS：Only considering about the economics,DPH is the most economical and effective medicine in the treatment of epilepsy.Due to small number of studies,large-scale and high quality studies are required for further validation of the conclusion.