2Boulet L P,FitzGerald J M,Levy M L,et al.A guide to the translation of the Global Initiative for Asthma (GINA) strategy into improved care[J] .Eur Respir J,2012,39 ( 5): 1220-1229.
2McKenzie SA, Bush A. Difficult asthma in children. Thorax, 2002,57:915-916.
3Levy ML, Thomas M, Small I,et al. Summary of the 2008 BTS/SIGN British Guideline on the management of asthma. Prim Care Respir J, 2009,18:S1-S16.
4Strek ME. Difficult asthma. Proc Am Thorac Soc, 2006,3:116-123.
5Bateman ED, Hurd SS, Barnes PJ, et al. Global strategy for asthma management and prevention.. GINA executive summary. Eur Respir J, 2008,31:143-178.
6Araujo AC, Ferraz E, Borges Mde C, et al. Investigation offactors associated with difficult to-control asthma. J Bras Pneumol, 2007,33:495-501.
7Guerra S, Graves PE, Morgan WJ, et al. Relation of beta2-adrenoeeptor polymorphisms at codons 16 and 27 to persistence of asthma symptoms after the onset of puberty. Chest, 2005,128:609-617.
8Silverman RA, Boudreaux ED, Woodruff PG,et al. Cigarette smoking among asthmatic adults presenting to 64 emergency departments. Chest,2003,123 : 1472-1479.
9Thomson NC, Chaudhuri R. Asthma in smokers: challenges and opportunities. Curr Opin Pulm Med, 2009,15 :39-45.
10Varraso R, Siroux V, Maccario J, et al. Asthma severity is associated with body mass index and early menarche in women. Am J Respir Crit Care Med,2005,171:334-339.