干燥综合征患者抗着丝点B蛋白抗体检测分析

Detection and analysis of CENP-B antibody in patients with Sjgren's syndrome

目的探讨抗着丝点B蛋白(CENP-B)抗体在干燥综合征(SS)患者中的检测价值。方法对31例抗CENPB抗体阳性的干燥综合征患者和99例抗CENP-B抗体阴性的干燥综合征患者的临床特征和血清学资料进行统计学分析。结果抗CENP-B抗体阳性组和阴性组在口干、眼干、牙齿脱落上差异无统计学意义(P>0.05)。抗CENP-B抗体阳性组患者雷诺现象常见,脾肿大,关节、肝脏受累现象高于阴性组,差异有统计学意义(P<0.05);在免疫指标中,抗CENP-B抗体阳性组Ig G低于阴性组,Ig M则高于阴性组。抗CENP-B抗体阳性组的ANA核型主要为着丝点型与阴性组不同。结论抗CENP-B抗体阳性的SS患者与抗CENP-B抗体阴性的SS患者在许多临床表现及血清学指标上有显著不同;抗CENP-B可作为SS患者病情评估的重要指标。

Objective To explore the value of CENP - B in the diagnosis of Sjogren＇ s syndrome（SS）. Methods The data of 31 SS patients with Anti - CENP - B antibodies and 99 SS patients without Anti - CENP - B antibodies were analysised retro- spectively about the serological features and clinical manifestations. Results The differences in dry mouth, dry eyes, and teeth loss between the Anti - CENP - B antibodies positive group and the Anti - CENP - B antibodies negative group had no statistical significance（P 〉 0.05 ）. The predominant clinical features among Anti -CENP- B antibodies positive patients were higher prevalence of Raynaud＇ s phenomenon, splenomegaly, joint involvement, and liver involvement while a lower prevalence of cough, serum IgG（ P 〈 0.05 ）, the differences had statistical significance. In the immune index, CENP- B positive group IgG was lower than that of negative group, and IgM was higher than the negative group. The ANA karyotype of the positive CENP - B antibody group was mainly different from the wire point type and the negative group. Conclusion Anti - CENP - B antibody - positive patients with SS anti CENP - B antibody negative SS patients had significant differences in the clinical manifestations and serological markers, and it can be used as an important adjunct detection index in patients with SS.