中西医结合治疗阑尾周围脓肿患儿65例疗效观察及安全性探讨

Investigating the efficacy and safety of integrated TCM and western medicines on 65 children with periappendiceal abscess

目的探讨阑尾周围脓肿患儿采用中西医结合治疗的疗效及安全性。方法选择2009年2月至2014年3月我院接诊的65阑尾周围脓肿患儿进行研究,随机分为治疗组和对照组。治疗组33例患儿采用中西医结合治疗,对照组32例患儿采用保守西医抗感染疗法。比较2组患儿的退热时间、抗生素使用时间、腹痛消退时间、肠功能恢复时间、住院时间等指标。结果治疗组的退热时间短于对照组,二者比较,差异有统计意义(t=4.5496,P<0.01);治疗组抗生素使用时间、肠功能恢复时间、住院时间均明显短于对照组(P<0.01);治疗组腹痛消退时间短于对照组(t=3.5013,P<0.01);治疗组总有效率(96.96%)明显高于对照组(78.13%),2组比较差异有统计意义(u=5.3455,P<0.05);治疗组总并发症为18.18%,对照组为53.13%,2组比较差异有高度统计意义(χ2=8.6761,P<0.01)。结论中西医结合治疗阑尾周围脓肿患儿临床疗效显著,安全性较高,预后良好,值得临床推广。

Objective To investigate the clinical efficacy and safety of integrated TCM and western medicines in treating the periappendiceal abscess. Methods 65 patients with periappendiceal abscess from February 2009 to March 2014 in our hospital were researched, they were divided randomly into a treatment group and a control group. The treatment group had 33 patients, treated by integrated TCM and western medicines. The control group had 32 patients, using western routine treatment. Compare two groups＇ cooling time, time of using antibiotic, the fading ot abdominal pain, time to ambulation, intestinal function recovery time and hospitalization time. Results Cooling time in the treatment group was shorter than that in the control group, and there was a significant difference （t= 4. 5496,P〈0.01 ）. Time of using antibiotic, time to ambulation, intestinal function recovery time and hospitalization time of the treatment group were significantly shorter than those of the control group, there was a sig- nificant difference （ P〈0.01 ）. There was a significant difference between the treatment group and the control group in the fading of abdominal pain （ t = 3. 5013, P 〈 0. 01 ）. The overall response rate of the treatment group （96.96%） was higher than that of the control group （78.13%）, and the differences of the two groups were highly statistically significant （u=5. 3455, P〈0.05）. The total complication of the treatment group was 18.18%, and that of the control group was 53.13% , the differences of the two groups were statistically significant （X2 = 8. 6761, P〈0.01 ）. Conclusion Integrated TCM and western medicines has good clinical efficacy and is safe treating chil- dren with periappendiceal abscess, with favorable prognosis. It is worthy of promotion in clinic.