非瓣膜性心房颤动脑卒中危险因素的临床分析

An analysis of the factors leading to the illness of cerebral apoplexy in patients with nonvalvular atrial fibrillation

目的分析非瓣膜性心房颤动(nonvalvular atrial fibrillation,NVAF)患者发生脑卒中的有关危险因素。方法收集168例NVAF患者临床资料,比较纳入研究的心房颤动患者中合并脑卒中与未合并脑卒中患者的临床特征,分析非瓣膜性心房颤动患者发生脑卒中的危险因素。结果本研究中房颤合并脑卒中的患病率是27.4%。经统计学分析,高龄(年龄>75岁)、糖尿病病史、高血压病史、心力衰竭病史等是非瓣膜性心房颤动患者发生脑卒中的危险因素;多因素Logistic分析显示:年龄、高血压病史、LVEF<50%是发生脑卒中的独立危险因素。结论高龄、高血压病史、左室收缩功能障碍是非瓣膜性心房颤动患者发生脑卒中的独立危险因素。

Objective To recognize the factors that contribute to the illness of cerebral apoplexy in patients with nonvalvular atrial fibrillation （NVAF）.Method The clinical data of 168 NVAF patients were collected and compared with the data of those with no cerebral apoplexy.Case -control study was applied to identify the risk factors that contribute to the illness of cerebral apoplexy in patients with NVAF.Findings The morbidity rate of the subjects of our study was 27.38%.The univariate analysis we conducted indicated that senility（ 〉75 years）, diabetes, hypertension and heart failure were the leading factors resulting in cerebral apoplexy in patients with NVAF.And the multivariable logistic regression analysis indicated that senility, hypertension and left ventricular systolic dysfunction （LVEF 〈50%） were the independent factors that lead to cerebral apoplexy in patients with NVAF.Conclusion senility, hypertension and left ventricular systolic dysfunction were independent risk factors for the illness of cerebral apoplexy in patients with NVAF.