大剂量纳洛酮对不同昏迷程度脑出血患者的影响

Effect of large dose of naloxone on cerebral hemorrhage patients with different degrees of coma

目的研究大剂量纳洛酮对不同昏迷程度脑出血患者的神经功能(Glasgow昏迷评分)是否均具有显著的治疗作用。方法不同昏迷程度患者120例,分为轻、中、重3级,每级随机分为常规治疗组和纳洛酮治疗组各40例。治疗1周后分别对神经功能展开评估。结果对于轻、中度昏迷脑出血患者,常规治疗组和纳洛酮治疗组治疗1周后神经功能评分相比差异无统计学意义(P>0.05);而对于重度昏迷患者,常规治疗组和纳洛酮治疗组1周后神经功能评分差异有统计学意义(P<0.05);纳洛酮治疗组神经功能评分高于常规治疗组。结论早期使用大剂量纳洛酮治疗对重度昏迷脑出血患者神经功能恢复有益,而对轻、中度昏迷患者益处不明显。

Objective To study whether large dose of naloxone has a prominent therapeutical effect on the neurologic func‐tion（Glasgow coma scale） of cerebral hemorrhage patients with different degrees of coma.Methods According to different de‐grees of coma ,patients were divided to 3 grades（mild ,moderate and severe coma） ,and each grade was further divided into two groups randomly ：conventional therapy group and naloxone therapy group.Each group had 20 patients.Neurologic function was estimated after a week.Results For mild and moderate coma patients ,there were no significant differences in neurologic func‐tion score between the conventional therapy group and naloxone therapy group （P〉0.05）.But for severe coma patients ,there were significant differences in neurologic function score between the conventional therapy group and naloxone therapy group （P〈 0.05 ） . The neurologic function score of naloxone therapy group was higher than that of conventional therapy group.Conclusion In the early stage of cerebral hemorrhage ,large dose of naloxone is beneficial to restore the neurologic func‐tion of cerebral hemorrhage patients with severe coma ,but this treatment has inapparent benefit for the patients with mild , moderate coma.