坦度螺酮对冠状动脉粥样硬化心脏病合并抑郁焦虑患者疗效的研究

Study on the Clinical Efficacy of Tandospirone in Treating Depression and Anxiety Associated with Coronary Heart Disease

目的观察抗焦虑药坦度螺酮应用于冠状动脉粥样硬化心脏病(冠心病)合并抑郁焦虑患者的临床疗效。方法选择2011年1月至2013年12月在保定市第二医院接受治疗的冠心病合并抑郁焦虑患者114例,按照掷骰子法随机均分为试验组与对照组,各57例。对照组行常规治疗,试验组在常规治疗的基础上联合坦度螺酮治疗,20 mg/d,口服7 d后按照患者实际情况增加服用量,30 d为1个疗程,2个疗程后对患者抑郁焦虑、生活质量、治疗依从性、临床疗效以及不良反应进行评价。结果治疗后试验组汉密尔顿抑郁量表得分和汉密尔顿焦虑量表评分显著低于对照组[(21.40±3.63)分比(23.98±3.65)分,(12.78±3.64)分比(17.77±3.69)分,P<0.01],治疗后试验组生理、心理、社会、环境的生活质量方面评分显著高于对照组[(15.40±2.63)分比(13.20±2.65)分,(15.40±2.63)分比(13.2±2.7)分,(17.40±2.64)分比(15.61±2.60)分,(14.1±2.3)分比(12.4±2.3)分,均P<0.01]。试验组不良反应均较轻微,无需进行特殊处理即可自行消失。结论常规治疗联合坦度螺酮应用于冠心病合并抑郁焦虑患者疗效显著,且安全性较高。

Objective To observe the clinical efficacy of tandospirone in treating depression and anxiety associated with coronary heart disease.Methods A total of 114 patients with coronary heart disease compli-cated by depression and anxiety admitted in Baoding Second Hospital from Jan.2011 to Dec.2013 were divided into experimental group and control group randomly by rolling the dice,with 57 cases in each group. Patients in the control group received conventional therapy while patients in the experimental group received tandospirone on the basis of conventional therapy,20 mg/d,orally taken for 7 days,the dosage was increased according to the actual situation of the patients afterwards,taking 30 days for a course of treatment.After two courses,the patients′situation of depression and anxiety,quality of life,treatment compliance,clinical effica-cy and adverse reactions of the two groups were evaluated.Results After treatment,Hamilton depression scale and Hamilton anxiety scale of the experimental group were significantly lower than the control group [（21.40 ±3.63） scores vs （23.98 ±3.65） scores,（12.78 ±3.64） scores vs （17.77 ±3.69） scores, P〈0.01];after treatment,scores of quality of life in the experimental group,including physiology,psychol-ogy,society and environment were significantly higher than those in the control group [（15.40 ±2.63） scores vs （13.20 ±2.65） scores,（15.3 ±2.6） scores vs （13.2 ±2.7） scores,（17.40 ±2.64） scores vs （15.61 ±2.60） scores,（14.1 ±2.3） scores vs （12.4 ±2.3） scores,all P〈0.01].The adverse reactions of the experimental group were mild and disappeared without treatment.Conclusion Tandospirone com-bined with conventional treatment for depression and anxiety associated with coronary heart disease has signif-icant curative effect,with high safety.