多糖对肠道功能调节作用的研究进展

Advances in Researches on Regulatory Effect of Polysaccharides on Intestinal Tract Function

肠道是机体重要的消化器官,亦是共生微生物群的主要寄居场所,在维持机体正常生命活动如免疫和内分泌功能中发挥着重要作用。肠道功能紊乱与疾病的发生以及发展过程密切相关。近年来,多项研究结果显示,多糖具有肠道功能调节作用,包括通过作用于肠道黏膜参与机体免疫过程、保护肠道屏障结构和功能的完整性、调节肠道菌群组成以及刺激肠道内分泌。从伴随疾病过程中的肠道功能紊乱的角度,对多糖调节肠道功能的作用机制进行综述。

As an important digestive organ, intestinal tract is also dominated by symbiotic microbes. It plays a crucial role in maintaining human health, such as immunity and endocrine functions.Functional disorder of intestinal tract is closely related to the development of many diseases. Recently, many studies have indicated that polysaccharides have regulatory effect on the function of intestinal tract. The underlying mechanism includes involvement in immunity by affecting intestinal mucosa, protection of intestinal barrier, regulation of intestinal flora composition and stimulation of intestinal endocrine. This paper summarized the regulatory mechanisms of polysaccharides on the function of intestinal tract from the aspect of intestinal disorders in disease progression.