高山柏化学成分研究(Ⅰ)

Chemical constituents of Sabina squamata(1)

采用硅胶、Sephadex LH-20、HPLC半制备等方法,对高山柏(Sabina squamata)的化学成分进行了研究。结果表明:从高山柏植物中共分离得到9个化合物。这些化合物经过波谱数据分析并结合文献对照,分别鉴定为山达海松酸(1),3β-羟基山达海松酸(2),柳杉酚(3),5-羟基-7,4'-二甲氧基黄并酮(4),去甲丁香色原酮(5),柏木双黄酮(6),十九烷酸-2,3-二羟丙酯(7),胡萝卜苷(8),β-谷甾醇(9)。以上所有化合物均为首次从该植物中发现。研究结果丰富了高山柏的化学成分内容,为其今后的开发与利用提供了科学依据。

The constituents of Sabina squamata were isolated by silica gel,Sephadex LH-20 column chromatography and reversed-phase HPLC.Their structures were elucidated by anlalyzing their spectral data and comparing with the previously reported literatures.Nine compounds were identified as sandaracopimeric acid（1 ）,3b-hydroxysandara-copimeric acid（2）,sugiol（3）,5-hydroxy-7,4′-dimethoxuflavone（4）,noreugenin（5）,cupressuflavone（6）,onadecanoic acid-2,3-dihydroxypropylester（7）,daucosterol （8）,β-sitosterol （9）.All compounds were firstly isolated from this plant.The results not only enriched its chemical constituents of Sabira squamata ,but also would provide material basis for its development and utilization in the future.