肺结核抗体检测联合CRP检测判断HIV合并肺结核杆菌感染的效果研究

Significance of Combined Tuberculosis Antibody Detection with CRP Test in Determination of HIV Infection Combine Pulmonary Tuberculosis

目的分析肺结核抗体检测联合C反应蛋白(CRP)检测判断HIV合并肺结核杆菌感染的应用价值。方法采用试剂盒对46例HIV合并肺结核杆菌感染患者和40例HIV感染患者进行结合分枝杆菌抗体检测,并绘制受试者工作特征曲线(ROC),依据ROC曲线确定CRP诊断界点。结果单纯肺结核抗体检测灵敏度为52.2%(24/46),特异性为57.5%(23/40)。CRP临界点为4.91 mg/L,灵敏度为78.3%(36/46),特异性为57.5%(23/40)。串联检测灵敏度和特异性分别为43.5%(20/46)和70.0%(28/40),并联检测灵敏度和特异性分别为87.0%(40/46)和67.5%(27/40)。结论肺结核抗体检测串联CRP检测判断HIV合并肺结核杆菌感染的效果更优,具有临床应用价值。

Objective To analyze the clinical value of tuberculosis antibody detection combined with C-reactive protein（CRP） test in the determination of HIV infection combine puhnonary tuberculosis. Methods The serum CRP and tuberculosis antibody binding test in 46 cases of HIV and pulmonary tuberculosis infected patients and 40 cases of HIV infection patients with mycobacterial were determined by ELISA and immunoturbidimetric assay. The receiver operating characteristic curve （ROC） was used to determine the CRP diagnostic cutoff point. Results The detection sensitivity of tuberculosis antibody in the determination of HIV infection combine pulmonary tuberculosis was 52.2% （24/46）and with a specificity of 57.5 % （23/40）. The serum CRP critical point was 4.91 mg/L, sensitivity was 78.3 % （ 36/46 ） with a specificity of 57.5 % （ 23/40 ）. The sensitivity and specificity of series combined detection were 43.5% （20/46） and 70.0% （28/40）, and the parallel detection sensitivity and specificity were 87.0% （40/46）and 67.5% （27/40）. Conclusion The combined tuberculosis antibody detection with CRP could have better effects with clinical value on determination of the HIV combine pulmonary tuberculosis infection.