新型类嘌呤脱氧核糖核苷类化合物的合成

Synthesis of novel purine deoxy nucleoside ribose analogues

以1,3,5-三-O-苯甲酰基-2-脱氧-2-β-氟-α-D-核糖为原料,通过溴代、与4-氯吡咯[2,3-d]嘧啶的钠盐偶合、4-氯的氨基化等反应,设计合成了一系列具有新型结构的4-取代-9-(2′-脱氧-2′-β-氟-β-D-呋喃糖基)吡咯[2,3-d]嘧啶类化合物,其化学结构经核磁共振、高分辨率质谱分析确证;并且初步探讨了反应条件和反应机理.结果表明,以无水四氢呋喃为溶剂,密闭高压回流反应,反应产率较高.

4-Substituted -9- （2＇-deoxy-2＇-β-fluorine-β-D-furan glycosyl） pyrrolo [2,3-d] pyrimi- dine compounds were designed and synthesized with 1,3,5-three-O-benzoyl-2-deoxy-2-β-fluoro- a-D-ribose as raw materials. The structure of products were characterized by nuclear magnetic resonance and high resolution mass spectrometry analysis. Moreover, the reaction conditions and reaction mechanisms were preliminarily discussed. Results show that high reaction yield of target products can be obtained under high pressure and reflux reaction.