摘要
以1,3,5-三-O-苯甲酰基-2-脱氧-2-β-氟-α-D-核糖为原料,通过溴代、与4-氯吡咯[2,3-d]嘧啶的钠盐偶合、4-氯的氨基化等反应,设计合成了一系列具有新型结构的4-取代-9-(2′-脱氧-2′-β-氟-β-D-呋喃糖基)吡咯[2,3-d]嘧啶类化合物,其化学结构经核磁共振、高分辨率质谱分析确证;并且初步探讨了反应条件和反应机理.结果表明,以无水四氢呋喃为溶剂,密闭高压回流反应,反应产率较高.
4-Substituted -9- (2'-deoxy-2'-β-fluorine-β-D-furan glycosyl) pyrrolo [2,3-d] pyrimi- dine compounds were designed and synthesized with 1,3,5-three-O-benzoyl-2-deoxy-2-β-fluoro- a-D-ribose as raw materials. The structure of products were characterized by nuclear magnetic resonance and high resolution mass spectrometry analysis. Moreover, the reaction conditions and reaction mechanisms were preliminarily discussed. Results show that high reaction yield of target products can be obtained under high pressure and reflux reaction.
出处
《化学研究》
CAS
2015年第3期263-266,共4页
Chemical Research
基金
河南省科技创新杰出青年基金(094100510019)
河南省科技攻关计划资助项目(092102310021)
关键词
新型类嘌呤脱氧核糖核苷
合成
结构表征
novel purine deoxyribonucleoside synthesis structural characterization