急性心肌梗死患者血清S100A1表达及临床意义

The Serum Level of S100A1 in Patients with Acute Myocardial Infarction and Its Clinical Significance

目的：探讨急性心肌梗死（acute myocardial infarction,AMI）患者血清S100A1表达及临床意义。方法：选择2011年1月至2013年12月收治的AMI患者86例和健康对照30例,采用酶联免疫吸附试验（ELISA）法检测血清S100A1和血浆肌钙蛋白Ⅰ（cardiac troponinⅠ,c TnⅠ）水平;采用荧光免疫方法检测血清高敏C-反应蛋白（high-sensitivity C reactive protein,hs-CRP）和血清肌酸激酶同工酶（creatine kinase-MB,CK-MB）水平。结果：AMI组患者血清S100A1、hs-CRP、c TnⅠ、CK-MB水平明显高于对照组（P〈0.01）。血清S100A1水平与hs-CRP、c TnⅠ、CK-MB呈正相关（P〈0.01或0.05）。AMI患者发病初期血清S100A1水平持续升高,受试者工作特征曲线分析结果显示,曲线下面积为0.855（95%CI：0.814~0.889）,以S100A1水平114μg/L为临界值,诊断灵敏度为94.7%,特异度为88.9%。结论：血清S100A1在AMI初期迅速持续的升高,对AMI诊断敏感度性和特异度高,作为新的血清学指标在AMI早期诊断中有重要参考价值。

Objective： To investigate the serum levels of S100A1 in patients with acute myocardial infarction （AMI） and its clinical significance. Methods： The level of serum S100A1 and plasma cardiac troponin I （cTn I ） level in 86 patients with AMI and 30 control volunteers were detected by ELISA, and serum high-sensitivity C reactive protein （hs-CRP） and creatine kinase-MB （CK-MB） were detected by fluorescence immunoassay. Results： The levels of S100A1, hs-CRP, cTn I and CK-MB in patients with AMI group were significantly higher than those in the control group （P〈0. 01 ）. A significant positive correlation was found be- tween the serum level of S100Alwith hs-CRP, cTn I , CK-MB （P〈0. 01 or 0.05）. Serum S100A1 level continued to rise in the ear- ly onset of AMI. ROC analysis showed that the area under the curve （AUC） was 0. 855 （95%C1： 0. 814-0. 889） , the best S IOOA1 critical level was 114 μg/L , the diagnostic sensitivity was 94. 7% and the specificity was 88.9%. Conclusions： Serum S100A1 rap- id sustained elevates in the early of AMI. It is high sensitivity and specificity for diagnosis of AMI, and it can be used as a new sero- logical indexes in the diagnosis of early AMI, and it has an important reference value.