清肺止咳灵糖浆抗炎解热作用研究

Studies on Antipyetic and Anti-inflammatory Effects of Qingfeizhikeling Syrup

目的观察清肺止咳灵糖浆的抗炎、解热作用。方法 Wistar大鼠50只,体质量(200±20)g,雌雄各半,按体质量、性别随机分5组,每组10只,即空白对照组,清肺止咳灵高、中、低剂量组及阳性药对照组,高、中、低剂量给药。阳性药对照组灌胃强力枇杷露,空白对照组灌胃等体积的0.9%氯化钠注射液。每日1次,连续给药4 d。于第4日给药后1 h,先测大鼠注射酵母前体温,然后每鼠立即背部皮下注射20%酵母悬液2 m L,然后于1、2、3、4 h各测定和记录大鼠体温1次。结果清肺止咳灵对二甲苯所致小鼠耳壳炎症有明显的抑制作用。高、中、低剂量组分别与空白对照组比较,差异有统计学意义(P<0.01或P<0.05)。清肺止咳灵高、中、低剂量组在给药后2 h分别与给药前比较,差异均有统计学意义(P<0.01或P<0.05),高、中剂量组给药后3、4 h与给药前比较差异无统计学意义(P>0.05)。低剂量组给药后4 h与给药前比较无显著性差异(P>0.05)。结论清肺止咳灵糖浆具有显著的抗炎、解热作用。

Objective： To research the antipyetic and anti-inflammatory effects of Qingfeizhikeling syrup. Meth- ods： 50 wistar rats,weighing（200±20） g,25 females and 25 males,were randomly divided into 5 groups by weight and gender,namely,the control group,Qingfeizhikeling group with high dose,Qingfeizhikeling group with mid dose, Qingfeizhikeling group with low dose, and positive drug control group. Loquat syrup was gastrically perfused into the rats in positive drug control group while equivoluminal normal saline was gastrically perfused into the rats in control group. The treatment lasted for 4 days,each group once a day. Temperature of rats after injection was measured 1 hour after being given medicine on the fourth day, and then each rat was given subcutaneous injection of yeast suspension on its back,and then the temperature of rats were measured and recordedr one,two,three, and four hours after injection. Results： Qingfeizhikeling showed significant effect on Auricular inflammation induced by Xylene. The differences between high,middle,low dose group and blank control group showed significantly Statistical significance （P〈0.01or P〈 0.05）.Tempterament of high,middle,low dose group two hours after dosing were improved compared with before dosing （P〈 0.01 or P〈 0.05）. Tempterament of high,middle dose group 3 hours ,4 hours after dosing showed no differences compared with before dosing （P 〉 0.05 ）. Tempterament of low dose group 4 hours after dosing showed no differences compared with before dosing （P 〉 0.05）. Conclusion： Qingfeizhikeling syrup has a significant antipyetic and anti- inflammatory effect.