辅助生殖技术子代中低出生体质量危险因素研究

Study on risk factors of low birth weight infants from assisted reproductive technology

目的探讨辅助生殖技术子代中低出生体重儿发生的相关危险因素。方法选取2012年6月—2014年8月在郑州大学第一附属医院接受辅助生殖技术受孕分娩出的活产新生儿为研究对象,从生殖中心和产科提取所有接受辅助生殖技术治疗的病案资料,符合纳入标准的病例,用EXCEL软件建立数据库,计算机录入资料并整理数据后,采用检验及多因素Logistic回归等分析方法来探讨影响辅助生殖技术子代中低出生体重儿发生的危险因素。结果 287例符合纳入标准的辅助生殖技术子代。采用χ2检验等单因素分析,以α=0.05的检验水准共筛出7个相关影响因素进行多因素Logistic回归,在调整其它因素的影响后,胎儿数目(多胎)(OR=3.225,95%CI:1.673,6.215)、产时合并症(子痫)(OR=2.294,95%CI:1.156,4.553)、产时合并症(胎盘早剥、胎膜早破)(OR=3.845,95%CI:1.607,9.201)、分娩孕周(小于37周)(OR=11.018,95%CI:5.044,24.066)有统计学意义(P均<0.05)。结论多胎、产时合并子痫、产时合并胎盘早剥、胎膜早破、早产与辅助生殖技术子代低出生体质量密切相关。

Objective To investigate the risk factors of assisted reproductive technology on the low birth weight of the infants. Methods These live neonates are enrolled whose mum acceped assisted reproductive technology and delivered in our hospital from June 2012 to Aug. 2014. Search all the medical records after assisted reproductive technology in thc Center of Reproductive Medicine and Obstetrics, select the cases met inclusion criteria and record these informations：in the EXCEL database. Single factor analysis and multivariate Logistic regression analysis were conducted to explore the risk factors of the assisted reproductive technology on the low birth weight of the neonates. Results There were 287 neo- nates enrolled. In the single factor analysis, 7 of 19 indexes were statistically significant （P 〈 0.05 ）, while in the multivariate logistic regression analysis, there were 4 of 7 indexes with significance （ P 〈 0. 05 ）, which of those were multiple pregnancy （ OR = 3. 225,95 % CI ： 1. 673,6. 215 ）, intrapartum with eclampsia （ OR = 2. 294,95 % CI ： 1.156,4. 553 ）, pro- duction with placental abruption or premature rupture of membranes （ OR = 3. 845,95% CI ： 1. 607,9. 201 ）, gestational age less than 37 weeks（ OR = 11. 018,95% C1：5.044,24. 066）. Conclusion Multiple pregnancy,intrapartum with ec- lampsia, production with placental abruption or premature rupture of membranes and gestational age less than 37 weeks are closely related to the low birth weight of the infants born after assisted reproductive technology.