奥曲肽与生长抑素治疗肝硬化食道静脉破裂出血比较

Comparative analysis of Octreotide and somatostatin in treatment of cirrhotic esophageal variceal bleeding

目的比较奥曲肽与生长抑素治疗肝硬化食道静脉破裂出血的临床效果。方法通过对2009年4月至2014年11月进行治疗的476例肝硬化食道静脉破裂出血患者进行分组,其中对照组患者给予奥曲肽治疗,实验组患者实施生长抑素治疗。观察比较两组患者的止血效果和不良反应差异。结果实验组患者的有效止血率为84.46%,不良反应发生率为8.82%,对照组患者的有效止血率为86.55%,不良反应发生率为7.98%,两组止血效果和不良反应发生率比较无显著性差异(P>0.05)。结论针对肝硬化食道静脉破裂出血患者采用奥曲肽或生长抑素均有较好的临床效果。

Objective To compare the clinical effect of octreotide and somatostatin esophageal variceal bleeding in cirrhosis. Methods Grouping by April 2009 to November 2014 in our hospital for treatment of 476 cases of esophageal variceal bleeding in patients with cirrhosis of the liver, where the control group were treated with oetreotide, somatostatin therapy for patients with the experimental group. Two groups of patients were compared hemostatic effect and adverse differences. Results The patients in the experimental group was 84. 46% effective hemostasis, adverse reactions was 8. 82% in the control group of patients with an effective rate of 86. 55% bleeding, adverse reaction rate was 7.98% , two hemostatic effect and incidence of adverse reactions There was no significant difference （ P 〉 0. 05 ）. Conclusion For cirrhotic patients with esophageal variceal bleeding octreotide or somatostatin have better clinical results.