呼吸中间神经元及呼吸网络模型的动力学分析

DYNAMICAL ANALYSIS OF RESPIRATORY INTERNEURON AND RESPIRATORY NETWORK MODEL

呼吸节律的产生起源于Pre-Btzinger复合体,这其中包含了Pre-Btzinger神经元在内的许多种呼吸神经元的参与,这些呼吸神经元和肺通过突触联系构成了脑桥-髓质的动态呼吸网络.由于目前对于呼吸节律产生和变化的网络机制尙不完全清楚,因此,本文从非线性动力学角度入手,通过构造与实际结构比较接近的呼吸网络模型,分别考察了网络中单个Pre-Btzinger中间神经元多样性的发放模式以及网络中群体神经元周期性和同步性的放电变化.数值结果为进一步揭示呼吸节律的产生和调控机制提供了一定的帮助.

The generation of respiratory rhythm originates from a population of Pre-Botzinger Complexs, and many kinds of respiratory neurons including the Pre-Botzinger neuron have been suggested to participate in this process, and meanwhile, these respiratory neurons together with the lung constitute a dynamic respiratory network through synaptic connections. The network mechanisms responsible for the generation and variation of respiratory rhythms are still unclear, so this paper explored the issue from the perspective of nonlinear dynamics. By con- structing a respiratory network model, whose architecture is very similar to the realistic respiratory anatomic struc- ture, we separately investigated the diverse firing patterns in the single Pre-Botzinger interneuron, and the period- ic and synchronous firing activities of the neuronal populations. The obtained model results may provide us some clues in further understanding the mechanisms for the generation of respiratory rhythms.