高血压并高同型半胱氨酸血症的治疗与动脉硬化的关系

The relationship between treatment of hyperhomocysteinemia and arteriosclerosis in hypertension

目的探讨高血压合并高同型半胱氨酸血症与动脉粥样硬化的相关性。方法选取100例急性缺血性脑卒中患者为研究对象,根据DSA检验血管狭窄度情况分为狭窄组和无狭窄组,比较2组基本资料;根据患者血压和Hcy情况分为正常组、单纯高Hcy血症组、单纯高血压组和高血压合并高Hcy血症组,比较4组血管狭窄情况。结果狭窄组患者高血压、糖尿病、高脂血症发生率明显高于无狭窄组,血压和Hcy水平明显高于无狭窄组,差异具有统计学意义(P<0.05)。正常组、单纯高Hcy血症组、单纯高血压组和高血压合并高Hcy血症组患者血管狭窄发生率逐渐升高,应用直线回归分析获得方程:Y=15.54+13.62X,差异具有显著性(F=788.508,P<0.01)。结论高血压及高Hcy血症与动脉粥样硬化具有正相关性,高血压相对于高Hcy血症在对动脉粥样硬化发生发展的影响中作用更为主导。

Objective To investigate the relationship between treatment of hyperhomocysteinemia （Hcy） and arteriosclero‐sis in patients with hypertension.Methods 300 cases with acute ischemic stroke as research objects were divided into stenosis group and non‐stenosis group according to stenosed degree of blood vessels detected by DSA technology ,and basic information was compared in two groups. Based on the blood pressure and Hcy ,all cases were classified as normal group ,simple Hcy group ,simple hypertension group and combination group with hypertension and Hcy ,comparing vascular stenosis of the 4 groups.Results The incidence of hypertension ,diabetes ,hyperlipidemia in stenosis group were obviously higher than that in non‐stenosis group ,and the blood pressure and the level of Hcy also had the same result ,with statistical significance between the two groups （P〈0.05）. The stenosis rate of blood vessels increased gradually in order of normal group ,simple Hcy group ,simple hypertension group and combination group. The equation was got by application of linear regression analysis ：Y=15.54＋13.62X（F= 788.508 ,P〈0.01）.Conclusion Hypertension and Hcy have positive correlation with atherosclerosis. Com‐pared with Hcy ,hypertension plays more important role in the occurrence and development of atherosclerosis.