静脉溶栓治疗以频发TIA为临床表现的急性脑梗死疗效观察

Observation of intravenous thrombolytic therapy for acute cerebral infarction patients with main manifestation of clustering TIA

目的观察静脉溶栓治疗频发TIA为临床表现的急性脑梗死患者的疗效及预后。方法选择我院2008-01-01—2013-12-31以频发TIA为临床表现的急性脑梗死静脉溶栓患者56例为治疗组,选择同期未行溶栓治疗的患者30例为对照组,采用NIHSS评分及改良的Rankin评分评价早期疗效及远期预后。结果 2组患者溶栓前ABCD2评分(6.12±3.49vs 5.78±4.13,P=0.23)、DWI阳性率(39.28%vs 36.67%,P=0.19)差别无统计学意义。溶栓后早期治疗有效率(51.78%vs 30.00%,P=0.001)、远期预后预后良好率(48.21%vs 33.33%,P=0.003)差别具有统计学意义。在出血转化率方面(8.93%vs 6.67%,P=0.07)差异无统计学意义。结论以频发TIA为临床表现的急性脑梗死患者静脉溶栓治疗安全有效。

Objective To observe the effect and prognosis of acute cerebral infarction patients with main manifestation of clustering TIA treated by intravenous thrombolytic therapy. Methods 56 with acute cerebral infarction patients with clustering TIA as clinical manifestation treated by intravenous thrombolytic therapy in our hospital from 2008 to 2013 were collected as treatment group ,and 30 patients without thrombolytic therapy in the corresponding period were selected as control group . NIHSS and modified Rankin Scale were used to evaluate early therapeutic effect and long‐term prognosis .Results There were no significant differences between the two groups in ABCD2 scale（6.12 ± 3.49 vs 5.78 ± 4.13 ,P=0.23） and positive rate of DWI（39.28% vs 36.67% ,P=0.19） before treated by thrombolysis .The differences were statistically significant in the effec‐tive rate of in early stage after thrombolytic therapy （51.78% vs 30.00% ,P=0.001） and the rate of benign prognosis（48.21%vs 33.33% ,P=0.003）. The rate of hemorrhagic transformation showed no statistical difference between two groups （8.93%vs 6.67% ,P=0.07）. Conclusion It is safe and effective of intravenous thrombolytic therapy for acute cerebral infarction pa‐tients with clustering TIA as clinical manifestation .