阿司匹林与低分子肝素钠联合治疗进展性脑梗死的临床疗效

Clinical efficacy of aspirin and low molecular heparin sodium for progressive cerebral infarction

目的探讨阿司匹林与低分子肝素钠联合治疗进展性脑梗死的临床疗效。方法收集2012-10—2014-08我院就诊的155例进展性脑梗死患者,随机分为对照组77例,研究组78例,对照组口服阿司匹林肠溶片治疗,研究组采用阿司匹林肠溶片及低分子肝素钠联合治疗,比较2组临床疗效、NIHSS评分、ADL评分。结果研究组总有效率89.74%,对照组75.32%,2组疗效差异有统计学意义(P<0.05)。治疗后2组NIHSS评分明显降低,ADL评分明显升高,研究组治疗后NIHSS评分较对照组明显较低,ADL评分明显较高,差异有统计学意义(P<0.05)。研究组治疗后PLT、Fg较治疗前及对照组治疗后显著降低,PT、APTT明显延长,差异有统计学意义(P<0.05)。且2组均未见不良反应。结论阿司匹林与低分子肝素钠联合治疗进展性脑梗死临床疗效好,可改善患者NIHSS评分及ADL评分,可以在临床推广应用。

Objective To investigate the clinical efficacy of aspirin and low molecular weight heparin in the treatment of progressive cerebral infarction.Methods 155 cases with progressive cerebral infarction from October 2012 to August 2014 in our hospital were randomly divided into the control group with 77 cases and the study group with 78 cases ,the control group was treated with enteric‐coated aspirin tablets ,the study group received combination therapy of low molecular weight heparin based on control group. Clinical efficacy ,NIHSS score and ADL score of the two groups were compared.Results The total ef‐fective rates of the study group and the control group was 89.74% ,75.32% ,the difference was statistically significant （P〈0.05）. After treatment ,the NIHSS scores were significantly lower and ADL scores were significantly higher in two groups , and NIHSS scores in study group were significantly lower than that in control group ,ADL score was significantly higher（P〈0.05）. The levels of PLT ,Fg in study group after treatment were significantly lower than those before treatment and those in the control group after treatment ,and PT ,APTT were significantly prolonged ,the differences were significant（P〈0.05）.And there were no adverse events in the two groups.Conclusion The treatment of aspirin combined with low molecular weight heparin for progressive cerebral infarction has better clinical efficacy ,which can improve the patient＆#39;s NIHSS score and ADL score and be widely applied for the clinical application.