摘要
1例1岁男性患儿玩耍时自行将其母亲放置茶几的氯霉素片2片（共0.5 g）吞入口中，约4.5 h后出现烦躁哭闹、恶心、呕吐、腹胀、面色轻微青紫、呼吸困难、心率快。实验室检查示二氧化碳结合力14.0 mmol／L，肌酸激酶137 U ／L，肌酸激酶同工酶45.0 U／L，乳酸脱氢酶635 U／L，肌红蛋白弱阳性。心电图示房颤伴快速心室率。诊断（：1）氯霉素致灰婴综合征；（2）心肌损伤；（3）代谢性酸中毒可能。立即给予吸氧、纠正酸中毒、强心、利尿等对症治疗，但患儿很快出现面色青紫、口唇发绀、心力衰竭、肺水肿、意识丧失。服药后约10 h抢救无效死亡。
A one-year-old boy took 2 tablets of chloramphenicol（0. 5 g）and swallowed when playing alone,the tablets were put on the table by his mother. The boy developed dysphoria,nausea,vomiting, abdominal distention,slight cyanosis,dyspnea,and tachycardia 4. 5 hours after the accidental medication. Laboratory tests showed the following values：carbon dioxide-combining power 14. 0 mmol/L,creatine kinase 137 U/L,creatine kinase isoenzyme 45. 0 U/L,lactate dehydrogenase 635 U/L,myoglobin weakly positive. ECG showed atrial fibrillation with rapid ventricular rate. The boy was diagnosed as：（1）gray baby syndrome due to chloramphenicol;（ 2 ） myocardial injury;（ 3 ） possibly complicated with metabolic acidosis. He underwent comprehensive treatments immediately including oxygen inhalation,inotropic agents,and diuresis. The boy developed cyanosis on face and lip,heart failure,pulmonary edema,and unconsciousness. Finally, the boy died despite resuscitation attempts about 10 hours after the accidental swallowing of chloramphenicol.
出处
《药物不良反应杂志》
CSCD
2015年第2期142-143,共2页
Adverse Drug Reactions Journal
关键词
氯霉素
灰婴综合征
Chloramphenicol
Gray baby syndrome
