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Phosphine-promoted [3+2] cycloaddition between nonsubstituted MBH carbonates and trifluoromethyl ketones 被引量：2

Phosphine-promoted [3+2] cycloaddition between nonsubstituted MBH carbonates and trifluoromethyl ketones
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摘要 A phosphine-promoted [3 ＋ 2] cycloaddition from readily accessible MBH （Morita-Baylis-Hillman） carbonate and aryl trifluoromethyl ketone is described. The use of methyl vinyl ketone-derived allylic carbonate rather than common acrylate-derived counterpart renders the reaction pathway exclusive for 5-endo process, which enables the expeditious preparation of a range of trifluoromethylated 2, 3-dihydrofuran in a chemospecific manner. A phosphine-promoted [3 ＋ 2] cycloaddition from readily accessible MBH （Morita-Baylis-Hillman） carbonate and aryl trifluoromethyl ketone is described. The use of methyl vinyl ketone-derived allylic carbonate rather than common acrylate-derived counterpart renders the reaction pathway exclusive for 5-endo process, which enables the expeditious preparation of a range of trifluoromethylated 2, 3-dihydrofuran in a chemospecific manner.
作者 Hong-Yu Duan Juan Ma Zhe-Zhe Yuan Ri-Sheng Yao Wei Tao Fang Xu Hua Xiao Gang Zhao
机构地区 School of Medical Engineering Key Laboratory of Synthetic Chemistry of Natural Substances
出处 《Chinese Chemical Letters》 SCIE CAS CSCD 2015年第6期646-648,共3页 中国化学快报（英文版）
基金 supported by the National Natural Science Foundation of China (No.21302034) the Fundamental Research Funds for the Central Universities (No.2013HGQC0028)
关键词 Cycloaddition Allylic carbonate Ylides Trifluorornethyl ketones Cycloaddition Allylic carbonate Ylides Trifluorornethyl ketones
分类号 O621.25 [理学—有机化学]
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Chinese Chemical Letters
2015年 第6期

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