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Propylphosphonic anhydride(T3P~) catalyzed one-pot synthesis of α-aminonitriles

Propylphosphonic anhydride(T3P~) catalyzed one-pot synthesis of α-aminonitriles
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摘要 The Strecker reaction was performed via a one-pot three component condensation of hetero aromatic/ aromatic aldehydes, secondary amines and trimetylsilyl cyanide in the presence of propylphosphonic anhydride (T3P) to accomplish the corresponding α-aminonitriles. The main advantages of this method are very short reaction time and excellent yields. The Strecker reaction was performed via a one-pot three component condensation of hetero aromatic/ aromatic aldehydes, secondary amines and trimetylsilyl cyanide in the presence of propylphosphonic anhydride (T3P) to accomplish the corresponding α-aminonitriles. The main advantages of this method are very short reaction time and excellent yields.
出处 《Chinese Chemical Letters》 SCIE CAS CSCD 2015年第6期739-743,共5页 中国化学快报(英文版)
基金 the Board of Research in Nuclear Sciences (BRNS),Mumbai,India for providing the financial support (No.2012/37C/33/BRNS)
关键词 Strecker reaction α-Aminonitriles Propylphosphonic anhydride5-Fluoro-3-methyl-2-carbaldehyde Strecker reaction α-Aminonitriles Propylphosphonic anhydride5-Fluoro-3-methyl-2-carbaldehyde
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