少腹逐瘀汤加减治疗原发性痛经的临床疗效及对血PGE_2和PGF_(2α)的影响

Clinical efficacy of Shaofuzhuyu decoction on primary dysmenorrhea and its impact on the blood of PGE_2 and PGF_(2α)

目的观察少腹逐瘀汤加减治疗原发性痛经的临床疗效及对血PGE2和PGF2α的影响。方法将160例原发性痛经患者简单随机分为试验组85例和对照组75例,试验组采用少腹逐瘀汤加减治疗,对照组采用布洛芬治疗,观察2组治疗后的临床疗效,治疗前后主要症状、体征、血流变学及PGE2和PGF2α的变化情况。结果试验组治疗后总有效率明显高于对照组(P=0.000 1);治疗后2组症状及体征积分明显低于治疗前(P均<0.05),且治疗后试验组症状及体征积分明显低于对照组(P<0.05);治疗后2组全血黏度、血浆黏度、全血还原黏度、红细胞压积、纤维蛋白原和PGF2α均明显低于治疗前(P均<0.05),PGE2明显高于治疗前(P<0.05),且试验组治疗后血流变学、PGE2和PGF2α改善情况优于对照组(P均<0.05)。2组治疗期间均未出现明显不良反应。结论少腹逐瘀汤加减治疗原发性痛经临床效果好,可以明显缓解患者临床不适症状,可能通过增加血流量和调节PGE2和PGF2α来影响血管舒缩功能而发挥治疗作用。

Objective It is to observe the clinical efficacy of Shaofuzhuyu decoction on primary dysmenorrhea and its impact on the blood of PGE2 and PGF2α. Methods 160 cases of primary dysmenorrhea patients were randomly divided into the experimental group of 85 cases and the control group of 75 cases,and the experimental group were treated with Shaofuzhuyu decoction,while the control group were received ibuprofen for treatment. The clinical efficacy of the two groups after treatment,and the changes of main symptoms and signs,blood rheology,PGE2 and PGF2αbefore and after treatment were observed. Results The total effective rate of the experiment group after treatment was significantly higher than that in the control group（ P = 0. 000 1）. After treatment,the scores of symptoms and signs significantly reduced compared with that before treatment in both group（ P〈 0. 05）,and the decrease in experiment group was more significant than that in the control group（ P 〈0. 05）. After treatment,the levels of whole blood viscosity,plasma viscosity,whole blood reduced viscosity,hematocrit,fiber and PGF2αdecreased obviously,and that of PGE2 increased compared with that before treatment（ P 〈0. 05）,and the improvement of blood rheology,PGE2 and PGF2αin experiment group was more significant than that in the control group（ P〈 0. 05）.There was no obvious adverse reactions during the treatment. Conclusion Shaofuzhuyu decoction had a good clinical effect on primary dysmenorrhea,which could significantly alleviate the patient＇s clinical symptoms,possibly by increasing blood flow and regulation of PGE2 and PGF2αto influence vasomotor function and play a therapeutic role.