Ki-67和p53在乳腺癌中的表达与临床病理分期的关系

The relationship between the expression of Ki-67 and p53 in breast cancer and its clinical pathological stage

目的探讨蛋白Ki-67和p53表达与乳腺癌临床病理分期的关系及其对判定预后的价值。方法回顾性分析417例乳腺癌患者病理资料,并对Ki-67和p53的表达情况与临床分期的相关性进行分析。结果本研究共纳入417例乳腺癌患者,蛋白Ki-67阳性385例(92.3%),蛋白p53阳性155例(37.2%),三阴型56例(13.4%),非三阴型361例(86.6%)。蛋白Ki-67和p53的表达与乳腺癌病理组织分型有关(P均<0.05),而与发病时间、淋巴结转移、乳头浸润、TNM分期、病理组织分级、发病年龄、是否绝经、发病部位和直径等因素无关。在三阴性和非三阴性乳腺癌病理组织中,蛋白Ki-67表达差异无统计学意义(P>0.05),p53表达差异有统计学意义(P<0.05)。结论Ki-67和p53在乳腺癌中高表达,对判断预后有一定的价值。

Objective It is to approach the relationships of the expression of protein Ki-67 and P53 in breast cancer with its clinic pathological stage,and predict the value for prognosis. Methods The clinical data of 417 cases of breast cancer were analyzed retrospectively. The relationship of Ki-67 and p53 expression with clinical indexes was analyzed by correlation anal-ysis. Results 417 patients with breast cancer were included. In this study,385 cases（92. 3%）with Ki-67 positive,155 cases（37. 2%）with p53 positive;56 cases（13. 4%）were triple-negative breast cancer,361 cases（86. 6%）were nor-tri-ple negative breast cancer. The expression of Ki-67 and p53 protein was associated with the histopathological classification in breast cancer（all P﹤0. 05）,but with no difference in the factors including the time of disease symptom,lymph node metas-tasis,nipple of invasion,TNM stage,histopathologic classification,age,menopausal status,site of cancer and diameter. However,in the groups of triple-negative breast cancer and nor-triple negative,there were obviously difference in expression of p53（P﹤0. 05）,but nor in Ki-67（P﹥0. 05）. Conclusion High expression of Ki-67 and p53 in breast cancer has certain value in prognosis.