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帕金森神经病理性疾病的临床分析 被引量:12

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摘要 目的探讨帕金森病(PD)患者伴神经病理性疼痛的发病率、危险因素、发病机制和治疗。方法对136例原发性PD患者进行疼痛问卷调查,予以简易精神状态量表(MMSE)、汉密尔顿抑郁量表(HAMD)、汉密尔顿焦虑量表(HAMA)、Hoehn-Yahr(H-Y)分期、统一PD评分量表(UPDRS)、简易疼痛量表(BPI)及神经性症状和体征的利兹评估(LANSS)评估。结果 136例PD患者中88例(64.7%)伴有疼痛。过去24 h平均BPI为(2.72±1.48)分。伴疼痛的PD患者中64例(72.7%)有骨骼肌痛,4例(4.5%)有肌张力障碍,15例(17.0%)有中枢痛,9例(10.2%)有静坐不能,22例(25.0%)有根性神经痛。其中LANSS≥12分者有11例(12.5%)为神经病理性疼痛。Logistic回归分析显示焦虑为PD患者发生神经病理性疼痛的独立预测因素。结论 PD患者神经病理性疼痛治疗效果差,发病机制不明确,焦虑是PD神经病理性疼痛的危险因素。
出处 《现代中西医结合杂志》 CAS 2015年第18期1985-1987,共3页 Modern Journal of Integrated Traditional Chinese and Western Medicine
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