阿托伐他汀治疗糖尿病肾病血脂异常的疗效分析

Curative effect analysis on atorvastatin in the treatment of dyslipidemia of diabetic nephropathy

目的：探讨阿托伐他汀治疗糖尿病肾病血脂异常的临床效果。方法选取2012年1月~2014年1月在本院就诊的86例糖尿病肾病合并血脂异常患者作为研究对象，随机分为治疗组和对照组，各43例。对照组给予常规治疗，治疗组在对照组的基础上给予阿托伐他汀，连用3个月。比较两组治疗前后的尿白蛋白排泄率（UAER）、血清胆固醇（TC）、三酰甘油（TG）、低密度脂蛋白胆固醇（LDL-C）、高敏C反应蛋白（hs-CRP）水平以及疗效。结果观察组的总有效率为88.3%，显著高于对照组的65.1%，差异有统计学意义（P〈0.05）。观察组的TC、LDL、UAER水平显著高于对照组，差异有统计学意义（P〈0.05）。观察组的TG、hs-CRP水平与对照组比较，差异无统计学意义（P〉0.05）。结论阿托伐他汀治疗糖尿病肾病血脂异常效果显著，值得临床推广应用。

Objective To explore the clinical effect of atorvastatin in the treatment of dyslipidemia of diabetic nephropathy. Methods 86 patients with diabetes nephropathy and dyslipidemia from January 2012 to January 2014 in our hospital were selected and randomly divided into the observation group and the control group,43 cases in each group.The control group was given conventional treatment,the observation group were given atorvastatin on the basis of the control group for 3 months.The level of urinary albumin excretion rate （UAER）,total cholesterol （TC）,triglyceride （TG）,low density lipoprotein cholesterin （LDL-C）,high-sensitivity C-reactive protein （hs-CRP） and the curative effect before and after treatment in two groups was compared. Results The total effective rate of the observation was 88.3%, which was higher than 65.1% of the control group,with significant difference （P〈0.05）.The level of TC,LDL and UAER in the observation group was higher than that in the control group,with significant difference（P〈0.05）. There was no sig-nificant difference between the TG,hs-CRP in two groups （P〉0.05）. Conclusion The effect of atorvastatin in the treat-ment of dyslipidemia of diabetic nephropathy is significant,it is worthy of clinical promotion and application.