心力衰竭发病机制及药物治疗进展

Research progress on mechanism of heart failure and drug therapy

随着国人平均寿命的持续增加及冠心病和高血压的流行,心力衰竭患病率节节攀升,造成我国巨额的医疗负担,虽然抗心力衰竭起搏器、心室机械辅助装置等的应用取得了很大进展,但药物治疗仍是心力衰竭治疗的基石,针对目前的药物治疗,虽然有效减轻患者的症状及降低总病死亡,但这些药物往往因激活了神经内分泌系统,心力衰竭的发病率及病死率仍然居高不下,近20年来,对心力衰竭发生的病理生理学机制有了新的认识,在此基础上也有了一些新的药物,本文对此做一综述。

With the continuous increasing of Chinese average life span and the prevalence of coronary heart disease and hyper- tension. Morbidity of heart failure continues to rise, which has resuhed in huge medical burden to our country. Although the heart pacemaker and ventrieular mechanical assist device applications have made great progress, drug therapy is still the cornerstone of the treatment of heart failure. The current drug therapy has been proved benefit in relieving patients＇ symptoms and reducing the total mortality, but these drugs are also often due to activation of neuroendocrine system, morbidity and mortality of heart failure still remain at a high level. In recent twenty years, on the basis of people＇ s new understanding of the pathophysiology mechanism of heart failure. Some new drugs and old drugs, new indication have been found. This article will make a summary.