摘要
辣椒素受体(Transient receptor potential vanilloid type 1,TRPV1)是一类和痛觉传递密切相关的离子通道受体,在神经病理痛的发生、维持中发挥着重要作用。大量资料表明,电针具有较好的治疗神经病理痛的作用,同时有研究发现电针具有调节TRPV1表达的作用。本文主要综述TRPV1参与神经病理痛的中枢敏化调控机制以及电针干预作用的研究进展。
Transient receptor potential vanilloid type 1（TRPV1）is an ion channel receptor which closely related to pain transmission,and plays an important role in the incidence and maintenance of neuropathic pain（NP）. A large amount of data has indicated that electro-acupuncture（EA）has a good effect on NP treatment. Also studies have found that EA has a role in regulating the expression of TRPV1. This article mainly reviews the advance of TRPV1 involvement in the mechanisms of central sensation modulating in NP and the intervention of EA.
出处
《云南中医学院学报》
2015年第3期88-91,共4页
Journal of Yunnan University of Traditional Chinese Medicine
基金
国家自然科学基金(81303038
81473772)
浙江省自然科学基金(LY12H27015
LY14H270007
LY14H270002)
国家中医药管理局重点学科(针灸学)建设经费资助(国中医药发[2009]30号)
关键词
辣椒素受体
神经病理痛
中枢敏化
电针
综述
TRPV1
neuropathic pain
central sensation
electro-acupuncture
review
