肺炎衣原体感染与肺结核病的相关性

The Relationship Between Chlamydia Pnemnoffme Infection and Tuberculosis

目的探讨肺炎衣原体（chlamydia pneumoniae,Cpn）感染与肺结核感染的相关性。方法选取2010年1月～2013年12月在本院住院的100例确诊肺结核病患者（病例组）,均通过影像或培养确诊为肺结核;以同期本院健康体检筛选出的与病例组年龄及性别匹配的30岁以上健康人作为对照组,共100例。两组年龄、性别差异无统计学意义。应用酶联免疫吸附（ELISA）法检测血清肺炎衣原体特异性IgG、IgM抗体。感染判断标准为：急性感染：IgM（＋）,IgG（-）;慢性（隐性）感染：IgM（＋）,IgG（＋）;既往感染：IgM（-）,IgG（＋）。对IgM（＋）患者4周后复检。结果对照组、病例组肺炎衣原体总感染率分别为57.5%、97.0%,其中急性感染率分别为1.5%、11.0%,慢性感染率分别为3.0%、10.0%,既往感染率分别为53.0%、76.0%,急性感染率、慢性（隐性）感染率、既往感染率在病例组与对照组比较差异有统计学意义（P〈0.01）。对IgM（＋）患者4周后复检结果为：总感染率分别为57.4%、97.5%,其中急性感染率分别为1.4%、5.8%,慢性（隐性）感染率分别为3.0%、13.7%,既往感染率分别为53.0%、78.0%,急性感染率、慢性（隐性）感染率、既往感染率在病例组与对照组比较差异有统计学意义（P〈0.01）;患者4周后复检结果与复查前结果比较,差异有统计学意义（P〈0.01）。结论结核病感染者的肺炎衣原体IgG、IgM抗体阳性率远远高于健康对照组,并且总感染率高达97.0%,提示结核病感染几乎均合并肺炎衣原体感染,临床上治疗肺结核时应提高警惕。

Objective To explore the relevance of Chlamydia pneumoniae infection and tuberculosis Infection.Methods 100 cases of patients Form january 2010 to December 2013 in our hospital which diagnosed with tuberculosis patients（case group）,male 57 cases,female 43 cases,aged 39～75（59.8 ± 9.6）years old,All cases were diagnosed by imaging or cultured pulmonary tuberculosis;to the sameperiod in our hospital healthy patient group screened with age and sex-matched healthy people over the age of 30 as a control group,a total of 150 cases were male,56 cases,female 44 cases.Two groups of age,gender was no significant difference test analysis.Exclude all objects into bronchial pneumonia,strep throat,pneumonia,Alzheimer′s,fibromyalgia,chronic fatigue,prostatitis,lung cancer and autoimmune diseases.Enzyme-linked immunosorbent assay（ELISA）to detect Chlamydia pneumoniae-specific serum IgG,IgM antibodies,in-fection criteria：acute infections：acute infection ：IgM（＋）,IgG（-）;chronic（recessive）infection ：IgM（＋）,IgG（＋）;past infection：IgM（-）,IgG（＋）.For IgM（＋）patients four weeks after re-examination.Results The control group,the total cases of Chlamydia pneumoniae infection group were 57%,97%,including acute infection were 1.5%,11%,chronic infection rates were 3%,10%,previous infection rates were 53%,76%,acute infection,chronic（hidden）infection,previous infection case and control group,the difference was statistically significant（P〈0.01）,for IgM（＋）patients four weeks after the retest results：total infection rates were 57.5%,97.5%,including acute infection rates were 3.4%,5.8%,chronic（recessive）infection rates were 1.5%,13.7%,previous infection rates were 52.5%,78.0%acute infection rate,chronic（hidden）infection,previous infection case and control group,the difference was statistically significant（P〈0.01）;patients comparing four weeks after the retest results and review the results before,the difference was statistically significant（P〈0.01）.Conclusion TB infection Chlamydia pneumoniae IgG,IgM antibody positive rate is much higher than the healthy control group,and the overall infection rate of up to 97.5%,suggesting that almost all of the combined TB infection Chlamydia pneumoniae infection,the clinical treatment of tuberculosis should be vigilant.