铜绿假单胞菌注射液治疗恶性胸腔积液疗效观察

Clinical efficacy of PA-MSHA injection in treatment of malignant pleural effusion

目的：观察铜绿假单胞菌注射液（PA-MSHA）治疗恶性胸腔积液的临床疗效。方法选取恶性胸腔积液患者60例随机分为治疗组和对照组，每组30例。治疗组于胸腔内注入PA-MSHA；对照组于胸腔内注入顺铂。治疗30 d后对比2组患者临床疗效、Karnofsky评分及不良反应。结果治疗组总有效率为83．3％（25／30），对照组总有效率为53．3％（16／30），治疗组的总有效率高于对照组（χ2＝6．24， P ＜0．05）；治疗组治疗后Karnofsky评分显著高于治疗前[（53．1±6．9） vs．（67．9±2．3）分， t ＝-11．15， P ＜0．05]，对照组治疗后Karnofsky评分高于于治疗前[（51．5±9．5）分vs．（60．1±3．2）分， t ＝-4．70， P ＜0．05]，治疗组治疗后Karnofsky评分明显高于对照组，差异有统计学意义（ t ＝10．84， P ＜0．05）。治疗组Karnofsky改善率为80．0％，高于对照组53．3％（χ2＝4．80， P ＜0．05）。治疗组不良反应的发生率为46．7％（14／30），对照组为76．7％（23／30），治疗组的不良反应发生率低于对照组（χ2＝4．34， P ＜0．05）。结论 PA-MSHA治疗恶性胸腔积液，可明显提高临床有效率，改善患者生存质量，且不良反应轻微，值得在临床推广应用。

Objective To observe the clinical curative effect of pseudomonas aeruginosa injection （ PA-MSHA） in thetreatmentofmalignantpleuraleffusion.Methods 60patientswithmalignantpleuraleffusionwererandomlydividedinto treatment group and control group, 30 cases in each group.The treatment group was treated with intrapleural injection of PA-MSHA;the control group was treated with intrapleural injection of cisplatin.After 30 day’s treatment, clinical curative effect, Karnofsky score and adverse reaction were compared between the 2 groups.Results In the treatment group, the total efficien-cy was 83.3%（25/30） and the control group’s total efficiency was 53.3% （16/30）, the treatment group total efficiency was higher than that of the control group （χ2 =6.24, P 〈0.05）; in treatment group, after treatment, Karnofsky score was significantly higher than that before treatment [（53.1 ±6.9） vs.（67.9 ±2.3）, t =11.15, P 〈0.05],the control group af-ter treatment, Karnofsky score was higher than before treatment （51.5 ±9.5） vs.（60.1 ±3.2）, （ t =4.70, P 〈0.05）, in the treatment group after treatment, Karnofsky score was significantly higher than that of control group, the difference was sta-tistically significant （ t =10.84, P 〈0.05）.The treatment group’s Karnofsky improvement rate was 80%, which was higher than the control group’s 53.3%（χ2 =4.80, P 〈0.05）.Treatment group’s incidence of adverse reactions was 46.7%（14/30）, the control group was 76.7%（23/30）, and the adverse reaction occurred rate in the treatment group was lower than the control group （χ2 =4.34, P 〈0.05）.Conclusion PA-MSHA in treatment of malignant pleural effusion can significantly im-prove the clinical efficiency and improve the quality of life of patients, and adverse reaction was less, which is worthy of clini-cal application.