肺炎支原体感染与哮喘相关性的分析

CORRELATION ANALYSIS OF MYCOPLASMA PNEUMONIAE INFECTION AND ASTHMA

目的探讨肺炎支原体感染和支气管哮喘相关性,为支气管哮喘的诊治提供理论依据。方法选取在我院就诊的支气管哮喘患儿54例作为观察组,选取同期就诊的单纯上呼吸道感染患儿54例作为对照组。两组患儿均行嗜酸性粒细胞计数、白细胞介素-13(IL-13)、免疫球蛋白Ig E以及肺炎支原体抗体(MP-Ig M)的检测。对比两组患儿的MP-Ig M检测阳性率。根据观察组MP-Ig M检测结果分为MP-Ig M阳性组和MP-Ig M阴性组,对比MP-Ig M阳性组、MP-Ig M阴性组和对照组患儿的嗜酸性粒细胞计数、IL-13以及Ig E的检测结果。结果观察组MP-Ig M检测的阳性率为75.93%,对照组MP-Ig M检测的阳性率为27.78%,观察组显著高于对照组(p<0.05);MP-Ig M阳性组、MP-Ig M阴性组的嗜酸性粒细胞计数、IL-13水平和Ig E水平均显著高于对照组(均p<0.05);MP-Ig M阳性组的嗜酸性粒细胞计数水平为(538.18±41.63)×106/L,IL-13水平为(253.27±40.36)ng/L,Ig E水平为(327.13±56.91)k U/L,均显著高于MPIg M阴性(均p<0.05)。结论哮喘的发病与肺炎支原体的感染有关,临床应加强哮喘患儿的肺炎支原体检测,并加强肺炎支原体的抗感染治疗。

Objective To explore the relationship between Mycoplasma pneumoniae infection and bronchial asthma, and provide a theoretical basis for the diagnosis and treatment of bronchial asthma. Methods 54 cases of children with bronchial asthma were selected as the observation group, treatment of children with herpes infection of the upper respiratory tract of 54 cases as the control group. Two groups of children were assayed by eosinophil count, interleukin - 13 （ IL - 13 ） , immunoglobulin IgE （ MP - IgM ） and Mycoplasma pneumoniae antibody detection. The positive rate of MP - IgM test in two groups were compared. According to the observation group, MP - IgM detection results were divided into MP- IgM positive group and MP- IgM negative group. Positive contrast group, MP- IgM MP- IgM negative group and a control group of children with eosinophil count, IL- 13 and IgE were detected. Re- suits The positive rate of MP - IgM in children with observation group detection was 75.93% ; The positive rate of MP - IgM in children with control group of detection was 27.78% ; The positive rate of MP - IgM detection in chil- dren with the observation group was significantly higher than the control group （p 〈 0.05 ） ; The MP -IgM positive group, MP - IgM negative groups eosinophil count, the levels of IL - 13 and IgE levels were significantly higher than that of control group （ all p 〈 0.05 ） ; In MP - IgM positive group, Eosinophils count （ 538.18 ±41.63 ） ×106/L, IL - 13 level （253.27±40.36） ng/L and IgE level （327.13 ±56.91 ） kU/L were significantly higher than in MP - IgM negative group （ all p 〈 0.05 ）. Conclusion The incidence of asthma is associated with mycoplasma pneumonia infection, and we should strengthen the detection and anti - infection treatment of Mycoplasma pneumoniae in children with asthma.