妊娠肾病综合征对母婴影响及自拟中药治疗研究

Pregnancy Maternal Influence and Self- made Traditional Chinese Medicine for the Treatment of Nephrotic Syndrome

目的:研究与分析妊娠肾病综合征对母婴影响及采取自拟中药治疗疗效。方法:回顾性分析本院所收治60例妊娠期肾病综合征患者临床资料,并为观察组;并选取同期60例正常孕妇作为对照组进行比较。比较两组血压、生化指标、并发症、妊娠结局、新生儿发生呼吸系统疾病情况。结果:观察组收缩压及舒张压均明显高于对照组,且除白蛋白外,24 h尿蛋白定量、血清白蛋白、尿素氮、血肌酐均明显高于对照组,具有统计学意义(P<0.05)。观察组孕妇并发症率为30.00%(18/60)明显高于对照组8.33%(5/60)(P<0.05);观察组新生儿妊娠结局及呼吸系统发病率与对照组比较(P<0.05)。经治疗后,观察组临床治疗有效率为85.00%(51/60),且无明显性不良反应发生。结论:对于妊娠期肾病综合征患者来说,其血压、临床血生化指标均存在异常,同时患者具有较差妊娠结局且新生儿发生呼吸系统疾病率较高。因此,临床需及时采取相关措施干预,然采用自拟中药治疗取得较好疗效,值得进一步研究与分析。

Objective：To study the impact and self - made traditional Chinese medicine therapy for pregnancy nephrotic syn- drome. Methods ： A retrospective analysis of 60 cases admitted to this institution clinical data of patients with nephrotie syndrome during pregnancy was the observation group ; and select the same period 60 cases of normal pregnant women as a control group for comparison. Comparison of two groups blood pressure, biochemical indicators, complications, pregnancy outcome, neonatal respira- tory disease cases was carried out. Results：The observation group had significantly higher systolic and diastolic blood pressure, and the addition of albumin outside,24 h urinary protein, serum albumin, blood urea nitrogen and serum creatinine were significantly higher, with statistical significance （P 〈 0.05 ）. Maternal complications in the observation group was 30.00% （18/60） and was significantly higher than 8.33 % in control group （ 5/60 ） （ P 〈 0.05 ） ; observation group pregnancy outcomes and neonatal respir- atory morbidity compared with those of control group （ P 〈 0.05 ）. After treatment, observation group effective rate was 85.00% （51/60） ,with no significant adverse reactions. Conclusion：For patients with nephrotic syndrome during pregnancy, blood pres- sure, blood biochemistry clinical abnormalities are present, but poor pregnancy outcomes and neonatal respiratory disease rates are higher. Therefore, the clinic need to take timely measures to intervene, and then the use of self - made traditional Chinese medi- cine treatment can achieve better efficacy, worthy of further research and analysis.