基于介孔碳/离子液体复合膜电化学检测甲硝唑的应用研究

Electrochemical determination for metronidazole based on the hybrid film of ionic liquid and mesoporous carbon

以疏水性离子液体与介孔碳（CKM-3）复合材料修饰的电极直接电化学测定甲硝唑;研究发现,[OIMI][PF6]与CKM-3修饰的电极对甲硝唑的响应电流的大于[BIMI][PF6]与CKM-3修饰的电极,其线性范围为1.0＆#215;10-8～3.0＆#215;10-5mol L-1,检测下限为l＆#215;10-gmol L-1,具有较高的灵敏度和较强的实用性.

We described a novel electrochemical sensor for metronidazole, which was the hybrid film of the hydrophobic ionic liquid （IL） and mesoporous carbon （CKM-3）. 1-Butyl-3-methylimidazolium hexafluorophosphate （[BIMI][PF6]） and 1- Octyl-3-methylimidazolium hexafluorophosphate （[OIMI][PF6]） were dispersed in CKM-3 suspension, respectively. Then, the hybrid suspensions were coated on a clean glassy carbon electrode （GCE） to obtain [BIMI][PF6] -CKM-3/GCE and [OIMI][PF6]-CKM-3/GCE, and the results indicated that the [OIMI][PF6] -CKM-3/GCE has bigger response current for metronidazole than that of [BIMI][PFs]-CKM-3/ GCE. Under the optimal conditions, the [OIMI][PF6]-CKM-3/GCE presented linear response to metronidazole in the range of 1.0×10-8 - 3.0 × 10-5mol L-1, and its detection limit was 1 × 10-9 mol L-1. This sensor was used to detect metronidazole in real samples with satisfactory results.