骨宝丸结合介入治疗早期股骨头缺血性坏死的临床研究

Clinical Study on Gubaowan Combined with Interventional Therapy in the Treatment of Avascular Necrosis of Femoral Head at Early Stage

目的评价骨宝丸结合介入治疗对早期股骨头缺血性坏死的临床疗效。方法选取2011年3月至2012年1月我院收治的股骨头缺血性坏死患者60例（78髋）为研究对象,将患者随机分为治疗组和对照组各30例。治疗组介入治疗后给予骨宝丸和复方丹参滴丸,对照组介入治疗后仅给予复方丹参滴丸。治疗结束后所有病例均随访6个月,比较两组患者的临床疗效、Harris评分和Ficat分期的变化。结果治疗组治疗后和6个月后总有效率分别为93.33%、86.67%,均显著高于对照组的73.33%和46.67%,差异具有统计学意义（P〈0.05）。结论骨宝丸和复方丹参滴丸结合介入治疗对0～Ⅱ期股骨头坏死疗效显著,较复方丹参滴丸联合介入治疗在治疗后早期能较好地减轻甚至消除疼痛,增加股骨头血供,提高髋关节的功能评分。

Objective To evaluate the clinical efficacy of Gubaowan combined with interventional therapy in treating avascular necrosis of femoral head（ANFH） at early stage. Methods 60 ANFH patients（78 hips） treated in our hospital from March 2011 to January2012 were selected and randomly divided into treatment group（30 cases） and control group（30 cases）. The treatment group was given Gubaowan and compound Danshen dripping pill（CDDP） after interventional therapy, the control group was only given CDDP after interventional therapy. All patients were followed up for six months, and the clinical effect, Harris score and Ficat change of two groups were compared. Results The total effective rate of treatment group after treatment and after six months of the treatment were 93.33% and 86.67%respectively, significantly higher than 73.33% and 46.67% of control group, the difference was statistical（P〈0.05）. Conclusions The curative effect of Gubaowan and CDDP combined with interventional therapy in the treatment of ANFH at 0 ～Ⅱ stage is better than that of CDDP combined with interventional therapy, especially in reducing the hip pain, increasing the blood supply of femoral head and improving the score of hip joint function.