慢性阻塞性肺疾病急性发作期联合、动态测定CRP和PCT的意义

The Significance of Combined, Dynamic Detection of CRP and PCT in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease

目的探讨慢性阻塞性肺疾病急性发作期(AECOPD)患者的C反应蛋白(CRP)和降钙素原(PCT)的动态变化。方法采取前瞻性、连续观察性方法,测定80例AECOPD患者入院第0、24、48小时的CRP和PCT(分别记录为CRP0、CRP1、CRP2和PCT0、PCT1、PCT2),分析CRP、PCT和死亡、住院天数之间的关系。结果 CRP、PCT水平和AECOPD患者住院天数、死亡有正相关关系,CRP1和住院天数相关性最高,PCT1和死亡相关性最高。结论联合、动态测定CRP和PCT,可以早期发现、早期治疗AECOPD患者的细菌感染,及时调整抗感染方案,判断疾病严重程度和预后。

Objective To investigate the dynamic changes of C-reactive protein（CRP） and procalcitonin（PCT） in patients with acute exacerbation of chronic obstructive pulmonary disease（AECOPD）. Methods With the prospective continuous observation method, the concentrations of CRP and PCT of 80 AECOPD patients on the adoptions of the 0 hour, the 24 thhour, and the 48thhour（recorded as CRP〈0,CRP1, CRP2 and PCT0, PCT1, PCT2, respectively） were detected. And then the relationships between CRP, PCT and death, days of stay-in-hospital were analyzed. Results There were positive co-relationships between the CRP, PCT levels and death, days of stay-in-hospital. The co-relationship between CRP1 and days of stay-in-hospital was the highest, the co-relationship between PCT1 and death was the highest. Conclusions It is the combined, dynamic detections of CRP and PCT that could help to find out and treat the bacteria infection earlier in patients with acute exacerbation of chronic obstructive pulmonary disease, to adjust the anti-infection program, and to judge the severity of the disease and prognosis.