阿奇霉素治疗小儿支原体肺炎的临床疗效观察

Clinical Effect Observation of Azithromycin in the Treatment of Children with Mycoplasma Pneumonia

目的观察阿奇霉素与红霉素治疗小儿支原体肺炎不同的临床效果及不良反应。方法选取我院2013年4月至2014年4月收治的92例小儿支原体肺炎患者,按就诊顺序分为观察组和对照组各46例。所有患者均进行常规治疗,观察组在此基础上给予阿奇霉素治疗,对照组在此基础上给予红霉素治疗。比较两组临床疗效及不良反应发生情况,记录患者肺干湿啰音消失时间、咳嗽消失时间以及住院时间。结果观察组总有效率为93.48%,明显高于对照组的76.74%;观察组的住院时间、咳嗽消失时间、哮鸣音消失时间和湿罗音消失时间均明显短于对照组;观察组的不良反应发生率为6.52%,明显低于对照组的28.26%;两者相比差异均具有统计学意义(P<0.05)。结论阿奇霉素治疗小儿支原体肺炎比红霉素疗效好,不良反应少,值得临床广泛推广。

Objective To observe the different clinical effects and adverse reactions of azithromycin and erythromycin in the treatment of children with mycoplasma pneumonia. Methods 92 cases of children with mycoplasma pneumonia admitted to our hospital from April 2013 to April 2014 were selected and divided into observation group and control group according to the registration order, with46 cases in each group. All patients were treated with routine treatment, the observation group was given azithromycin on this basis, and the control group was given erythromycin based on the routine treatment. The clinical effects and adverse reactions between two groups were compared, the hospitalization time and the disappearing time of cough and wheezy sound were recorded. Results The total effective rate of observation group was 93.48%, significantly higher than 76.74% of control group; the hospitalization time and the disappearing time of cough, wheezing rale, moist rale of observation group were significantly shorter than those of control group; the incidence of adverse reactions of observation group was 6.52%, significantly lower than 28.26% of control group; all the difference was statistical（P〈0.05）.Conclusions Azithromycin has better curative effect and fewer adverse reactions than erythromycin in the treatment of children with mycoplasma pneumonia, which is worthy of clinical application.