美托洛尔与缬沙坦对男性高血压患者性功能影响的对比研究

Treatment effect of metoprolol and valsartan on the sexual function of male patients with hypertension

目的：探讨不同抗高血压药物对男性患者性功能的影响,为中青年男性高血压患者临床用药提供参考。方法：选取男性高血压患者328例,随机分为两组,使其有可比性。A组162例,给予美托洛尔治疗;B组166例,给予缬沙坦治疗。采用IIEF-5量表对治疗前后两组患者性功能进行评价,并对治疗后3个月患者性功能进行评级。结果：经过治疗两组患者血压差别不大;治疗前两组患者IIEF-5得分差别不大。经过治疗,A组患者勃起功能、性高潮能力、性欲、性交满意度、总体满意度得分分别为（19.16±1.17）分、（19.02±1.27）分、（19.38±1.31）分、（19.23±1.22）分和（19.89±1.38）分;B组患者分别为（23.17±2.29）分、（23.02±2.11）分、（23.72±2.37）分、（23.58±2.17）分和（23.93±2.23）分,A组明显低于B组,两组比较差异有统计学意义（P〈0.05）。治疗3个月后,A组患者性功能I级IV级者分别占37.65%、35.19%、14.81%和12.35%;B组患者分别占54.82%、32.53%、10.24%和2.41%,A组患者性功能明显低于B组,两组比较差异有统计学意义（P〈0.05）。结论：缬沙坦在治疗高血压的同时可以有效改善男性高血压患者的性生活质量,为中青年男性高血压患者提供了更好的用药选择。

Objectives： To investigate the effects of different antihypertensive drugs on the sexual function of male patients and provide reference for clinical use in middle - aged patients with hypertension. Methods： 328 male hypertensive patients were randomly divided into two groups, 162 cases in group A who received metoprolol treatment and 166 cases in group B who received valsartan treatment. IIEF -5 scale was used to evaluate sexual function of two groups before and after treatment. After treatment for 3 months, the sexual function of the patients was rated. Results： After treatment, the blood pressure of two groups was not very different ; before treatment, the IIEF - 5 score of the two groups was not very different. After treatment, the erectile function, orgasm ability, sexual desire, intercourse satisfaction and overall satisfaction score of group A were （ 19.16 ± 1.17） points, （ 19.02± 1.27） points, （19.38± 1.31） points, （19.23 ± 1.22 ） points and （19.89 ±1.38） points, respectively, while （23.17 ± 2.29） points, （23.02 ± 2.11） points, （23.72 ±2.37） points, （23.58 ± 2.17） min and （23.93 ± 2.23 ） points in group B. The result of group A was significantly lower than these in group B, with statistically significant difference （ P 〈 0. 05 ）. After 3 months of treatment, the sexual function of group A from grade I - IV accounted for 37.65% , 35. 19% , 14.81% and 12.35% , respectively, while accounting for 54.82% , 32.53%, 10. 24% and 2.41% in group B, respectively. Sexual function of group A was significantly lower than that of group B, with statistically significant difference （ P 〈 0. 05 ）. Conclusion： In the treatment of hypertension, valsartan can effectively improve the quality of life of male hypertension patients, which is a good medication choice.