多囊卵巢综合征患者早孕期促性腺激素水平与体重指数的相关性研究

Correlation study of HCG levels and body mass index in very early pregnancy for PCOS

目的:探讨多囊卵巢综合征患者早孕期HCG水平与体重指数(BMI)的相关性。方法:采用回顾性分析的方法进行研究,以2010年6月至2013年3月在我院治疗妊娠的1102例多囊卵巢综合患者为研究对象,所有患者均采用内分泌调节后促排卵自然同房妊娠,记录排卵后第16d HCG水平及当天的体重指数,其中有1042例检测,60例未检测。1042例孕妇中有138例为双胎妊娠,904例为单胎妊娠。结果:多胎妊娠孕妇排卵后第16d HCG水平明显高于单胎妊娠孕妇,相比差异有统计学意义(P<0.05)。单胎妊娠孕妇体重指数<20kg/m2与血清平均HCG水平明显高于体重指数>35kg/m2的孕妇,相比差异有统计学意义(P<0.05)。而对于多胎妊娠孕妇,随着体重指数的升高,血清平均HCG水平也相应降低,相比差异有统计学意义(P<0.05)。在早孕期间血清HCG水平与BMI指数呈负相关,单胎妊娠中相关指数为-0.012,多胎妊娠中相关指数为-0.03。结论:多囊卵巢综合征患者早孕期HCG水平与体重指数呈负相关,可能是由于肥胖孕妇脂肪组织中的某些因子影响了种植胚胎的HCG分泌,而这个规律是否适合所有早孕妇女,流产是否与此有关等问题还有待于进一步的研究。

Objectives ： To study the correlation of HCG levels and body mass index in very early pregnancy for PCOS. Methods： Retrospective analysis method was used to study 1102 cases with PCOS treated in our hospital from June 2010 to March 2013 as the objects. All of the patients received natural pregnancy after endocrine regulation stimulating ovulation. Information of serum HCG concentrations on 16th day after ovulation induction and BMI were recorded. There were 904 mothers with singleton pregnancy and 138 mothers with multiple pregnancies. Resuits： Mean HCG concentration of multiple pregnancies group was higher than that of singleton pregnancies group （ P 〈 0. 05 ）. In singleton pregnancies group, mean serum HGG concentration of women with BMI 〈 20kg/m2 was more than that of women with BMI 〉 35kg/m2 （P 〈 0. 05 ）. In mLdtiple pregnancies group, mean serum HGG con centration decreased with the BMI increasing （ P 〈 0. 05）. There was a significant negative association between BMI and HCG concentrations, in singleton pregnancies group （regression coefficient- 0. 012） and in multiple pregnancies group （ regression coefficient - 0. 03 ）. Condusion： Serum HCG concentrations for PCOS patients are negatively associated with BMI. One possible explanation may be the effect of adipose tissue - derive molecules on HCG secretion of the implanting embryo. But whether the law is suitable for all early pregnant women and whether abortion is related still need to be further stdied.