米索前列醇直肠给药与口服给药预防产后出血临床效果对比

Effect analysis of misoprostol with rectal drug delivery in the prevention of postpartum hemorrhage

目的:探讨米索前列醇紧贴直肠前壁给药预防产后出血的效果。方法:以我院2013年7月至2014年7月间收治的顺产产妇320例为研究对象,随机分为直肠给药组和口服给药组,两组患者在胎儿娩出后皆使用10U缩宫素,直肠给药组配以400μg米索前列醇直肠给药,口服给药组则为同样剂量口服用药,比较两组患者产后出血情况、子宫血液循环情况和不良反应发生率。结果:直肠给药组患者产后出血量和出血率均低于口服给药组,子宫血液循环状态优于口服给药组,并发症发生率低于口服给药组,其差异均有统计学意义(P<0.05)。结论:使用米索前列醇通过直肠给药相比于口服,可以更有效的预防产后出血。

Objectives： To analyze the clinical effect of misoprostol with rectal drug delivery in the prevention of postpartum hemorrhage. Methods： 320 vaginal delivery women were selected and randomly divided into two groups; all received oxytocin （10U）. The misoprostol was used in the objective group with rectal drug delivery and it was used in the control group with oral delivery. The clinical effect was compared between the two groups. Results： The bleeding and blood loss rate in the objective group were lower. The uterine blood circulation in the ob-jective group was better. The incidence of adverse reactions in the objective group was lower too. Conclusion： It is of positive effect to use misoprostol with rectal drug delivery in the prevention of postpartum hemorrhage.