体外受精-胚胎移植中影响胚胎种植成功的因素回归分析

Regression analysis of influential factors on embryo implantation of vitro fertilization-embryo transfer

目的:对影响体外受精-胚胎移植种植的相关因素进行探讨分析,以期为临床成功实施体外受精-胚胎移植提供参考。方法:对我院2009年3月至2013年5月接受体外受精-胚胎移植的211例妇女的临床资料进行回顾分析,其中种植成功55例,种植失败156例,分析患者年龄、不孕原因等身体因素,体外受精方式、外源性促性腺激素使用量等临床治疗因素对影响体外受精-胚胎移植种植成功率进行logistic回归分析。结果:最终logistic分析结果显示,患者年龄、受精成功率、优质胚胎率、移植胚胎卵裂球数目对胚胎种植影响较大、年龄(OR=0.870,P<0.01)、受精成功率(OR=0.921,P<0.05)、优质胚胎率(OR=1.025,P<0.05)、移植胚胎卵裂球数目(OR=0.889,P<0.01),其中年龄与体外受精-胚胎移植是否成功呈显著负相关关系,其他因素成显著正相关关系。结论:体外受精-胚胎移植种植成功受多方面因素的影响,临床上应予以重视。

Objectives： To investigate the factors that influence the success rate of vitro fertilization - embryo transfer, providing reference for the clinical success of vitro fertilization - embryo transfer. Methods： 211 women who were accepted vitro fertilization - embryo transfer in our hospital from March 2009 to May 2013 in our hospital were selected, including 55 cases of successful planting and 156 cases of failure. Their clinical data were retrospectively analyzed. The factors that influence the success rate of vitro fertilization - embryo transfer included age, cause of infertility, patients＇ physical factors, vitro fertilization methods and the use of exogenous gonadotropins and etc. Logistic Regression analysis was done. Results： The final logistic regression analysis showed that age, fertilization success rate, quality embryo rate, the number of balls cleavage embryos had greater impact on embryo implantation, Age （OR = 0. 870, P〈0. 01）, fertilization succoss rate （OR = 0.921, P〈0. 05）, high-qual- ity embryo rate （ OR = 1. 025, P 〈0. 05）, the number of balls cleavage embryos （ OR = 0. 889, P 〈0. 01 ）, in which age and IVF - embryo transfer success were in a significanlL negative correlation and other factors were in significant positive correlation with IVF - embryo transfer success. Conclusion： IVF - planting success is affected by many factors and attention should be paid on the clinic.