罗布麻宁及其苷在植物界中的分布及药理活性研究进展

Distribution of Apocynin and Its Glycosides in Plant Kingdom and Its Pharmacological Research Progress

现代生物医学研究表明,罗布麻宁为还原型烟酰胺腺嘌呤二核苷酸磷酸(NADPH)氧化酶抑制剂,其作为工具药广泛用于呼吸、神经、心血管等系统疾病的机理研究。为了开发富含罗布麻宁及其苷的天然药物资源,本文综述了罗布麻宁及其苷在植物界中的分布情况,并对其药理作用进行概述。现有研究资料表明,罗布麻宁及其苷广泛分布于植物界,迄今已在60余科上百种植物中发现,集中分布于鸢尾科、玄参科、夹竹桃科等植物类群中。以上综述可为新药资源开发提供线索,并为罗布麻宁治疗疾病的深入机理研究提供参考。

Modern biomedical researchindicates that apocynin is an inhibitor of NADPH oxidase, which has been widely used for mechanism research of respiratory, nervous and cardiovascular diseases as a tool drug. To develop apocynin and its glycosides enriched natural resources, their distributionand pharmacological researches are overviewed. The data show that apocynin and its glycosides arewidespread in plant kingdom, which have been found in over 60 families among hundreds of plants and mainly distributed in Iridaceae, Scrophulariaceae, Apocynaceae, etc. This paperprovidcs clues to new medicine resources development and further pharmacological research.