妊娠妇女不同孕期血清维生素A、E水平检测分析

Clinical study of serum levels of vitamin A and E on stages of pregnancy

目的分析妊娠早、中、晚期血清维生素A、E水平,评价妊娠期维生素的营养状况,指导孕妇妊娠期合理补充维生素。方法收集2013年1月至2014年8月我院就诊孕妇妊娠早、中、晚期血清样本共10279份,采用高效液相色谱法定量测定血清维生素A、E的浓度,并与正常人群血清维生素A、E的浓度作比较。结果妊娠早、中、晚期血清维生素A检测值分别为（0.33±0.08）mg/L、（0.37±0.10）mg/L、（0.33±0.15）mg/L,总体异常率占25.84%,以缺乏为主要表现（25.38%）。缺乏率在妊娠早期（38.8%）大于妊娠晚期（35.92%）;妊娠早、中、晚期血清维生素E检测值分别为（9.12±2.43）mg/L、（14.32±3.54）mg/L、（15.79±5.11）mg/L,总体异常率占6.08%,以过量为主要表现（5.78%）。妊娠早期异常率最低（1.26%）,随着孕周增加,维生素E异常率也逐渐增加,妊娠晚期达到最高（15.52%）,为维生素E过量。结论妊娠各期血清维生素A、E水平不同,妊娠早期维生素A缺乏,而妊娠晚期维生素E则存在过量情况,因此重视孕期维生素A、E水平监测,合理正确补充,对保障母婴安全有重要意义。

Objective To study and analysis of s erum levels of vitamin A,E in early,middle and late pregnancy,Evaluation of vitamin nutritional status in pregnancy,to guide pregnant women vitamin supplements in pregnancy.Methods Collecting total of 10279 serum samples from pregnant women during early,middle and late pregnancy between January 2013 and August 2014 in our hospitol,using High performance liquid chromatography（HPLC）method to quantitative determination of the concentration of serum vitamin A and E,and compared with normal people serum concentrations of vitamin A,E.Results In early,middle and late pregnancy Vitamin A serum values were 0.33±0.08mg/L,0.37±0.10mg/L,0.33±0.15mg/L,total abnormal rate was 25.84%,main performance is lack（25.38%）.Lack of rate in the first trimester of pregnancy（38.8%）is greater than in late pregnancy（35.92%）.Vitamin E serum values were 9.12±2.43mg/L,14.32±3.54mg/L,15.79±5.11mg/L,total abnormal rate was 6.08%,with excess（5.78%）as the main performance.Abnormalities in early pregnancy is the lowest（1.26%）,with the increase of gestational age,the abnormal rate of vitamin E also gradually increased,reached the highest in late pregnancy（15.52%）,all characterized by excessive vitamin E.Conclusion The serum levels of vitamin A,E are different in pregnancy period,the abnormal rate each are not identical,vitamin A is given priority to with lack in the first trimester of pregnancy,while vitamin E is the presence of excess in late pregnancy.Therefore attaching great importance to the monitoring vitamins A,E and other micronutrients level in pregnancy,strengthening perinatal education and guiding the rational correct prenatal vitamins supplement have important significance to guarantee matenalr and fetal safety.