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创伤性颅脑损伤的氢波谱临床研究 被引量：4

Clinical research of proton magnetic resonance spectroscopy for traumatic craniocerebral injury
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摘要 目的探讨氢波谱(1 HMRS)分析对创伤性颅脑损伤(TCI)的损伤程度及预后的临床指导意义。方法将54例TCI患者和10例志愿者行氢波谱检查,分析损伤组与对照组,损伤组患侧与对侧的N-乙酰天门冬氨酸(NAA)、胆碱(Cho)、肌酸(Cr)、乳酸(Lac)测定值及NAA/Cho,NAA/Cr,Cho/Cr比值的变化。结果 NAA/Cho,NAA/Cr比值损伤组较对照组以及损伤组患侧脑白质较对侧同一部位正常脑白质(NAWM)显著降低,而Cho/Cr比值显著升高。NAA/Cho,NAA/Cr,Cho/Cr比值变化与TCI患者GCS,GOS具有相关性。结论氢波谱(1 HMRS)分析对创伤性颅脑损伤的早期诊治具有重要的临床指导意义。 Objective To investigate the clinical significance of proton magnetic resonance spectroscopy（1 HMRS）on extent and prognosis of traumatic craniocerebral injury（TCI）.Methods 30 TCI patients and 10 volunteers were accepted proton magnetic resonance spectroscopy.Observe the change of N-acetyl aspartate（NAA）,choline（Cho）,creatine（Cr）,lactate（Lac）,NAA/Cho,NAA/Cr and Cho/Cr of ipsilateral and contralateral white matter of brain.Results The value of NAA/Cho and NAA/Cr in white matter of patients was decreased significantly than control group,however the value of Cho/Cr was significantly increased.The value changes of NAA/Cho,NAA/Cr,Cho/Cr in white matter of patients was correlated with GCS and GOS.Conclusion Proton magnetic resonance spectroscopy has an important guiding significance for the early diagnosis and treatment of traumatic craniocerebral injury.
作者 李在雨 陈云鹏 杨正月 李钢
机构地区 深圳大学附属罗湖医院脑外科
出处 《中国实验诊断学》 2015年第6期909-911,共3页 Chinese Journal of Laboratory Diagnosis
基金 惠州市科技计划重点项目课题资助(20140805)
关键词 创伤型颅脑损伤 氢质子磁共振波普 N-乙酰天门冬氨酸 胆碱 肌酸 Traumatic Craniocerebral injury Proton magnetic resonance spectroscopy（^1 HMRS） N-acetylaspartate Choline compound Creatine compound
分类号 R651.15 [医药卫生—外科学]
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参考文献11

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中国实验诊断学
2015年 第6期

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