摘要
目的观察他克莫司联合替米沙坦对中老年IgA肾病患者肾功能和血清分泌型IgA、转化生长因子-β1(TGF-β1)的影响。方法选择2013年7月-2014年7月我院肾内科中老年IgA肾病80例为研究对象,随机分为对照组和观察组,每组各40例。对照组:给予常规药物干预;观察组:在常规药物的基础上给予他克莫司和替米沙坦。比较两组患者干预前后肾功能和血清分泌型IgA、TGF-β1的变化。结果对照组患者的肾功能在干预前后,差异无统计学意义(P>0.05);观察组干预后肾功能较干预前明显改善(P<0.05)。观察组干预后血清分泌型IgA和TGF-β1较干预前均明显降低,且低于对照组干预后水平(P<0.05)。结论他克莫司联合替米沙坦能明显改善中老年IgA肾病患者的肾功能,并能降低血清分泌型IgA、TGF-β1的表达,延缓病情进展。
Objective To observe the effect of tacrolimus and telmisartan to the serum secretory IgA,transforming growth factor-β1of middle and aged patients with IgA nephropathy.Methods 80 diabetic nephropathy cases were selected as study objects in our hospital from 2013 July to 2014 July.The patients were divided into control group and observation group randomly.Each group has 40 cases.The control group was given conventional drug intervention.Based on control group,the observation group was given tacrolimus and telmisartan for three months.The renal function and serum secretory IgA,transforming growth factor-β1was compared before and after intervention.Results The renal function of control group before and after intervention had no significant difference（P〉0.05）.The renal function of observation group after intervention recorded a marked improvement（P〈0.05）After intervention,the serum secretory IgA,transforming growth factor-β1of the observation group reduced obviously,and was lower than that of control group after intervention.（P〈0.05）.Conclusion Tacrolimus and telmisartan can obviously improve the renal function of middle and aged patients with IgA nephropathy and reduce the expression of secretory IgA and transforming growth factor-β1to delay the disease.
出处
《中国实验诊断学》
2015年第6期915-917,共3页
Chinese Journal of Laboratory Diagnosis
