川芎平喘合剂对COPD患者血管内皮功能的调节作用

Effects of ChuanXiong PingChuan Mixture on Vascular Endothelial Function of COPD Patients

目的:探讨川芎平喘合剂对COPD患者血管内皮功能的影响。方法:将COPD患者68例按随机数字表法随机分为对照组和治疗组各34例。对照组给予常规基础治疗,治疗组在常规治疗的基础上给予川芎平喘合剂。治疗3个月后观察2组患者血管内皮生长因子(VEGF)、ET-1、v WF及中医证候积分等指标变化情况。结果:1)临床疗效比较:对照组、治疗组总有效率分别为86.7%和93.5%,2组比较差异具有统计学意义(P<0.05)。2)2组治疗后ET-1、v WF较治疗前明显下降,VEGF水平较治疗前明显升高,其差异具有统计学意义(P<0.05);治疗后治疗组ET-1、v WF较对照组明显下降,VEGF较对照组明显升高,其差异具有统计学意义(P<0.05)。3)中医症状积分:治疗后2组患者中医症状积分均较治疗前明显降低(P<0.05);治疗组治疗后症状积分较对照组明显降低,其差异具有统计学意义(P<0.05)。结论:川芎平喘合剂可缓解COPD患者症状,调节、改善患者血管内皮功能,其机制可能与调节v WF、VEGF水平,抑制ET-1分泌有关。

Objective：To find out the effects of ChuanXiong PingChuan mixture on vascular endothelial func-tion of COPD patients. Methods：Sixty-eight patients were allocated to the control group and the treatment group ac-cording to random number table method, 34 cases in each group. The control group received routine treatment, and the treatment group took ChuanXiong PingChuan mixture on the basis of routine treatment. To observe vascular en-dothelial growth factor （VEGF）, endothelin-1 （ET-1）, von willebrand factor （vWF） and syndrome scales of the pa-tients in both groups before and after treating for three months. Results：1） the comparison of clinical effects：total ef-fective rates of the control group and the treatment group were 86.7%and 93.5%respectively, the difference had sta-tistical meaning between both groups（P〈0.05）. 2） The levels of ET-1 and vWF lowered after treating in both groups than these indexes before treating, the level of VEGF increased significantly compared with before treating, the dif-ference showed statistical meaning （P〈0.05）;after treating, the levels of ET-1 and vWF of the treatment group de-creased compared with the control group, the levels of VEGF in the treatment group improved compared with that of the control group, the difference demonstrated statistical meaning （P〈0.05）. 3） TCM symptom integral：symptom in-tegrals of both groups after treating were lower than these before treating obviously （P〈0.05）;symptom integral of the treatment group after treating was reduced evidently compared with the control group notably, the difference pre-sented statistical meaning （P〈0.05）. Conclusion： ChuanXiong PingChuan mixture could alleviate COPD patients＇ symptoms, regulate and improve vascular endothelial function of the patients, and its mechanism might be related to regulating the levels of vWF and VEGF, inhibiting the secretion of ET-1.