养肝活血清利方治疗肝硬失代偿期化随机平行对照研究

Treatment of Yanggan Huoxue Qingli Soup Decompensated Cirrhosis Randomized Controlled Study

[目的]观察养肝活血清利方治疗肝硬化失代偿期疗效。[方法]使用随机平行对照方法,将70例住院患者按抛硬币法简单随机分为两组。对照组35例拉米夫定,100mg/次,1次/d;阿德福韦酯,10mg/次,1次/d。治疗组35例养肝活血清利方(甘草、干蟾蜍各5g,白术、柴胡、桃仁、赤白芍各10g,蛰虫12g,黄精、党参、黄芪、枸杞子、女贞子各15g,丹参、山药各20g;黄疸加栀子15g,茵陈20g;腹胀腹痛加小茴香10g,玄胡15g,大腹皮20g,蒲公英30g;咳嗽胸水加白芥子、葶苈子各10g;腹水严重加大黄、椒目各5g,猪苓10g,厚朴、茯苓各12g,泽泻15g,防己20g;出血加三七末3g,血余炭10g,黑栀子12g);1剂/d,水煎200m L,早晚口服。连续治疗60d为1疗程。观测临床症状、ALT、AIB、A/G、TBIL、Child-Pugh评分、不良反应。治疗1疗程,判定疗效。[结果]治疗组痊愈22例,有效12例,无效1例,总有效率97.14%。对照组痊愈18例,有效10例,无效7例,总有效率80.00%。治疗组疗效优于对照组(P<0.05)。血液生化指标两组均有改善(P<0.01),治疗组改善优于对照组(P<0.01)。Child-Pugh评分两组均有改善(P<0.01),治疗组改善优于对照组(P<0.01)。[结论]养肝活血清利方治疗肝硬化失代偿期疗效满意,无严重不良反应,值得推广。

[Objective] To observe Yanggan Huoxue Qingli Soup, decompensated cirrhosis treatment efficacy. [Methods] randomized, parallel controlled method, 70 patients were hospitalized method is simple coin toss randomized into two groups. The control group of 35 patients with lamivudine, 100mg/second, 1/d; adefovir, 10mg/times, 1 times/d. Liver treatment group of 35 patients living serum Liberia（Gancao,Ganchanchu each 5g, Baizhu,Chaihu,Taoren,Chishao 10 g, Zechong 12 g, Huangjing,Dangshen,Huangqi,Gouqizi,Nvzhenzi 15 g, Danshen,Sahnyao 20g; jaundice plus Zhizi 15 g, Yinchen 20g; abdominal distension add Xiaohuixiang 10 g, Xuanhu 15 g, Dafupi 20 g, Pugongying 30g; cough, pleural effusion plus Baijiezi, Tinglizi 10g; severe ascites plus Dahuang,Jiaomu each 5g, Zhuling 10 g, Houpu,Fuling 12 g, Zexie 15 g, Fangji 20g; bleeding plus Sanqi 3g,Xueyutan 10 g, Heizhizi12g）; 1/d, decoction 200 m L, sooner or later orally. 60 d for a course of continuous treatment. Observation of clinical symptoms, ALT, AIB, A/G, TBIL, Child-Pugh score, adverse reactions. One course of treatment, to determine efficacy. [Results] The cure 22 cases, effective in 12 cases, one case, the total efficiency of 97.14%. The control group cured 18 cases, 10 cases, 7 cases, the total efficiency of 80.00%. Treatment group than the control group（P〈0.05）. Blood biochemical parameters improved in both groups（P〈0-01）, treatment group was better than that in the control group（P〈0-01）. Child-Pugh score improved in both groups（P〈0-01）, treatment group was better than that in the control group（P〈0-01）. [Conclusion]Treatment of Yanggan Huoxue Qingli Soup decompensated cirrhosis results were satisfactory, no side effects, worthy of promotion.