摘要
[目的]观察辨证分型联合西药治疗晚期胃癌疗效。[方法]使用随机平行对照方法,将40例住院患者按病志号抽签法简单随机分为两组。对照组20例丝裂霉素,第1d,10mg/次,1次/d,静注;阿霉素,第1、8d,30mg/次,1次/d,静注;0.5g5-氟脲嘧啶+1000m L 5%葡萄糖,1次/d,持续5d,静滴。治疗组20例辨证分型:瘀毒内阻,失笑散(五灵脂、生蒲黄各10g,蒲公英、龙葵、藤梨根、铁树叶、仙鹤草各30g,当归、延胡索、桃仁、赤芍各10g,白屈菜、藕节、玉竹各20g);痰湿凝结,海藻玉壶汤合二陈汤(陈皮、郁金、半夏、海藻、浙贝母、昆布各10g,甘草6g,茯苓15g,生牡蛎30g,全瓜蒌30g);脾胃虚寒,附子理中汤(党参20g,半夏、白术、陈皮、制附子各10g,干姜、草豆蔻各6g,补骨脂、猪苓各15g);气血两亏,十全大补汤(黄芪、党参各30g,白术、当归、茯苓各15g,枸杞子、菟丝子各12g,川芎、熟地黄、枳壳、白芍各10g,肉桂6g);均1剂/d,水煎200m L,早晚口服;西药治疗同对照组。连续治疗30d为1疗程。观测临床症状、病灶、生存率、不良反应。连续治疗2疗程,判定疗效。[结果]治疗组完全缓解1例,部分缓解8例,稳定10例,无效1例,总有效率95.00%。对照组完全缓解0例,部分缓解4例,稳定10例,无效6例,总有效率70.00%。治疗组疗效优于对照组(P<0.05)。生存率治疗组改善优于对照组(P<0.05)。[结论]辨证分型联合西药治疗晚期胃癌疗效满意,无严重不良反应,值得推广。
[Objective]To observe Syndromes Combined with Western treatment of advanced gastric cancer. [Methods] uses random parallel control method, 40 cases of hospitalized patients by disease Zhi No. balloting method is simple and randomized into two groups. Mitomycin group, the first 1d, 10mg/times, 1 times/d, intravenously; doxorubicin, first 1,8d, 30mg/times, 1 times/d, intravenously; 0.5g 5-fluorouracil + 1000 m L 5% glucose, 1 times/d, continuous 5d, intravenous infusion. Treatment group Syndromes: Ecchymosis resistance, Shixiaosan(Wulingzhi, Shengpuhuang 10 g, Pugongying,Longkui,Tengligen,Tieshuye,Xianhec ao 30 g, Danggui,Yanhusuo,Taoren,Chishao 10 g, Baiqucai,Oujie,Yuzhu 20g); phlegm coagulation, seaweed soup okho Erchen(Chenpi,Yujin,Banxia,Haizao,Zhebeimu,Kunbu 10 g, Gancao 6g, Fuling 15 g, Shengmuli 30 g, Quangualou 30g); stomach Deficiency, aconite soup(Dangshen 20 g, Banxia,Baizhu,Chenpi,Zhifuzi 10 g, Ganjaing,Caodoukou each 6g, Buguzhi,Zhuling each 15g); two blood loss, Shiquandabutang(Huangqi,Dangshen 30 g, Baizhu,Danggui,Fuling 15 g, Gouqizi,Tusizi 12 g, Chuanxiong,Shudihuang,Zhike, Baishao 10 g, Rougui 6g); both a / d, decoction 200 m L, sooner or later oral; Western medicine with the control group. 30 d for a course of continuous treatment. Observation of clinical symptoms, gastric lesions, survival rates, side effects. 2 courses of continuous treatment, to determine efficacy. [Results]Treated one case of complete remission, 8 cases were markedly effective in 10 cases, one case, the total efficiency of 95.00%. Healed 0 cases in the control group, 4 cases were markedly effective in 10 cases, 6cases, the total efficiency of 70.00%. Treatment group than in the control group(P〈0.05). Treatment group improved survival rates than the control group(P〈0.05). [Conclusion]Syndromes advanced gastric cancer combined with western medicine and western medicine alone, there was no significant difference in efficacy.
出处
《实用中医内科杂志》
2015年第6期99-101,共3页
Journal of Practical Traditional Chinese Internal Medicine
关键词
晚期胃癌
辨证分型
瘀毒内阻
痰湿凝结
脾胃虚寒
气血两亏
失笑散
海藻玉壶汤
二陈汤
附子理中汤
十全大补汤
丝裂霉素
阿霉素
5-氟脲嘧啶
病灶
生存率
中西医结合治疗
随机平行对照研究
advanced gastric cancer
syndromes
ecchymosis resistance
condensation dampness
spleen and stomach
blood loss
Shixiaosan
Okho seaweed soup
erchen
Fuzilizhong soup
Shiquandabutang
mitomycin
doxorubicin
5-fluorouracil
gastric lesions
survival
TCM and western medicine treatment
equivalent studies
randomized parallel group study