通心络联合西药治疗冠心病血脂随机平行对照研究

TXL combined with Western Intervention in Coronary Heart Randomized Controlled Study

[目的]观察通心络联合西药治疗冠心病血脂疗效。[方法]使用随机平行对照方法,将68例门诊及住院患者按抛硬币法简单随机分为两组。对照组34例抗凝、扩管、抗心绞痛等。治疗组34例通心络胶囊,1.04g/次,3次/d;西药治疗同对照组。连续治疗42d为1疗程。观测临床症状、TC、TG、HDL-C、LDL-C、红细胞压积、低切黏度、全血高切、血浆黏度、全血黏度、不良反应。治疗1疗程,判定疗效。[结果]治疗组痊愈12例,显效18例,有效2例,无效2例,总有效率94.12%。对照组痊愈8例,显效15例,有效2例,无效9例,总有效率73.53%。治疗组疗效优于对照组(P<0.05)。血脂水平两组均有改善(P<0.05),治疗组改善优于对照组(P<0.05)。血液流变学指标两组均有改善(P<0.01),治疗组改善优于对照组(P<0.01)。[结论]通心络联合西药治疗冠心病血脂疗效满意,无严重不良反应,值得推广。

[Objective] Tongxinluo combined with western intervention in coronary heart effect. [Methods] randomized, parallel controlled method, 68 cases of outpatient and inpatient simply by flipping a coin law randomly divided into two groups. The control group of 34 patients anticoagulant, diffuser, anti-anginal and other drugs. Treatment group, 34 patients Tongxinluo capsule, 1-04g/time, 3 times/d; Western medicine with the control group. 42 d for a course of continuous treatment. Observation of clinical symptoms, TC, TG, HDL-C, LDL-C, blood rheology indicators（hematocrit, low shear viscosity, high shear whole blood, plasma viscosity, whole blood viscosity）, adverse reactions. One course of treatment, to determine efficacy.[Results]The cure 12 cases, 18 cases markedly effective in 2 cases, 2 cases, the total efficiency of 94.12%. The control group recovered eight cases, effective in 15 cases, 2 cases, 9 cases, the total efficiency of 73.53%. Treatment group than the control group（P〈0.05）. Lipid levels improved in both groups（P〈0.05）, the treatment group than the control group improved（P〈0.05）. Hemorheology improved in both groups（P〈0.01）, treatment group was better than that in the control group（P〈0.01）. [Conclusion] TXL combined with western intervention in coronary heart results were satisfactory, no side effects, worthy of promotion.